Uncovering novel metabolic processes in eukaryotic cells

发现真核细胞的新代谢过程

• 批准号: DP180102729
• 负责人: Prof Malcolm McConville
• 金额: $ 37.13万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-05-17 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180102729
• 关键词: Uncovering; novel; metabolic; processes; eukaryotic

This project aims to investigate the origin and function of the large number of chemically undefined metabolites that occur in all cells. The project will utilise advanced analytical techniques, as well as computational and genetic approaches, to characterise the chemical structures of these metabolites and identity the enzymes involved in their synthesis and degradation. It will provide new information on the metabolic capacity of eukaryotic cells and allow the generation of more accurate models of metabolism. These outcomes have important biotechnology applications and will identify metabolic processes that underpin normal and disease states in animals and human cells.

该项目旨在研究存在于所有细胞中的大量化学上未定义的代谢物的来源和功能。该项目将利用先进的分析技术以及计算和遗传方法来表征这些代谢物的化学结构，并确定参与其合成和降解的酶。它将提供有关真核细胞代谢能力的新信息，并允许产生更准确的新陈代谢模型。这些结果具有重要的生物技术应用，并将确定支撑动物和人类细胞正常和疾病状态的代谢过程。