Targeting the metabolism of parasitic protozoa

针对寄生原生动物的代谢

• 批准号: nhmrc : GNT1154540
• 负责人: Prof Malcolm McConville
• 金额: $ 78.54万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-metabolism-parasitic-protozoa/1349146
• 关键词: Targeting; metabolism; parasitic; protozoa

Efforts to control the spread of devastating parasitic diseases, such as malaria, leishmaniasis, cryptosporidiosis and toxoplasmosis, have been limited by the inadequacy of current drug options. This proposal will utilize advanced analytical and computational approaches to identify aspects of host-pathogen metabolism that are essential for disease and use this information to prioritize new drug targets and develop antimicrobial drug leads.

由于目前可供选择的药物不足，控制疟疾、利什曼病、隐孢子虫病和弓形虫病等破坏性寄生虫病蔓延的努力受到限制。该提案将利用先进的分析和计算方法来确定对疾病至关重要的宿主-病原体代谢方面，并利用这些信息优先考虑新的药物靶点和开发抗菌药物先导。