Ontogenetic changes in heartbeat fluctuation and nonlinear interactions between neural oscillators

心跳波动的个体发生变化和神经振荡器之间的非线性相互作用

基本信息

批准号：
07680931
负责人：
KAWAHARA Koichi
金额：
$ 1.54万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07680931/
关键词：
chick embyos heartbeat period fluctuation ontogeny neural oscillators nonlinear interactions between oscillators

项目摘要

In this research project, we have tried to elucidate the ontogenetic changes of heart beat period fluctuations in chick embryos. The results obtained from this study are summarized as follows :(1) Electrocardiogram (ECG) colud be recorded from chick embryos at about the 10th day of incubation (DI). During this period, there was little fluctuation in heartbeat periods. However, the heartbeat fluctuation, especially the low-frequency components of it, became greater as the DI increased.(2) The spectrum analysis of heartbeat fluctuation disclosed that the power spectral density of the heartbeat periods was almost flat like a white noise in the early period of incubation. However, the spectral density became inversely proportional to the frequency as embryos grew up, and finally showed the characteristics of 1/f fluctuation at the 17th or 18th DI.(3) A spectral component representing the respiratory modulation of the heartbeat was first observed at about 10th DI,and the component became greater during development of the chick embryos.(4) A model study using mutually interacting nonlinear BVP oscillators showed that a bunch of oscillators functions as a single "limit-cycle oscillator" when the coupling strength between them is strong.All the above results suggested that the autonomic nervous control of the heart may fully developed by about the 17ty DI,and that the spectral changes of heartbeat fluctuation may reflect the ontogenetic process of the autonomic nerve innervation of the heart.

在这个研究项目中，我们试图阐明雏鸡胚胎中心跳周期波动的个体发生变化。从这项研究中获得的结果总结如下：（1）在孵育10天（DI）大约第10天，从雏鸡的胚胎记录心电图（ECG）COLUD。在此期间，心跳时期几乎没有波动。然而，随着DI的增加，心跳波动，尤其是其低频组成部分。（2）心跳波动的频谱分析表明，心跳时期的功率谱密度几乎像孵化早期的白噪声一样平坦。然而，随着胚胎的增长，光谱密度与频率成反比，最终显示出1/f在第17或第18 di期间的波动的特征。当它们之间的耦合强度很强时，一堆振荡器充当单个“极限循环振荡器”。上述结果表明，心脏的自主神经神经控制可能会被大约170 di完全发展，并且心跳波动的光谱变化可能反映了心脏内部自治性静脉内部内部内部的遗传学过程。