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Ontogenetic changes in heartbeat fluctuation and nonlinear interactions between neural oscillators

心跳波动的个体发生变化和神经振荡器之间的非线性相互作用

基本信息

批准号：
07680931
负责人：
KAWAHARA Koichi
金额：
$ 1.54万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07680931/
关键词：
chick embyos heartbeat period fluctuation ontogeny neural oscillators nonlinear interactions between oscillators

项目摘要

In this research project, we have tried to elucidate the ontogenetic changes of heart beat period fluctuations in chick embryos. The results obtained from this study are summarized as follows :(1) Electrocardiogram (ECG) colud be recorded from chick embryos at about the 10th day of incubation (DI). During this period, there was little fluctuation in heartbeat periods. However, the heartbeat fluctuation, especially the low-frequency components of it, became greater as the DI increased.(2) The spectrum analysis of heartbeat fluctuation disclosed that the power spectral density of the heartbeat periods was almost flat like a white noise in the early period of incubation. However, the spectral density became inversely proportional to the frequency as embryos grew up, and finally showed the characteristics of 1/f fluctuation at the 17th or 18th DI.(3) A spectral component representing the respiratory modulation of the heartbeat was first observed at about 10th DI,and the component became greater during development of the chick embryos.(4) A model study using mutually interacting nonlinear BVP oscillators showed that a bunch of oscillators functions as a single "limit-cycle oscillator" when the coupling strength between them is strong.All the above results suggested that the autonomic nervous control of the heart may fully developed by about the 17ty DI,and that the spectral changes of heartbeat fluctuation may reflect the ontogenetic process of the autonomic nerve innervation of the heart.

在本研究项目中，我们试图阐明鸡胚胎中心跳周期波动的个体发生变化。本研究的主要结果如下：(1)鸡胚在孵育第10天左右记录了心电图（ECG）。在此期间，心跳周期波动很小。然而，随着DI的增加，心跳波动，特别是其低频分量变得更大。(2)心跳波动的频谱分析表明，在孵化初期，心跳周期的功率谱密度几乎是平坦的，就像白噪声一样。但随着胚胎的生长，光谱密度与频率成反比，最终在第17或第18 DI时呈现1/f波动特征。(3)在第10 DI时首次观察到代表心跳呼吸调节的光谱分量，该分量在鸡胚发育过程中逐渐增大。(4)利用相互作用的非线性BVP振子进行的模型研究表明，当一组振子之间的耦合强度较强时，它们表现为单个“极限环振子”。以上结果提示心脏自主神经控制在17ty左右发育完全，心跳波动的频谱变化可能反映了心脏自主神经支配的个体发生过程。