Phylodynamics for Single Cell Genomics

单细胞基因组学的系统动力学

• 批准号: DP220101005
• 负责人: Prof Michael Stumpf
• 金额: $ 28.05万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-10-24 至 2025-10-23
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101005
• 关键词: Phylodynamics; Single; Cell; Genomics

This project generates the mathematical framework required to look at single cell data in developmental systems and tissues. All cells in a multi-cellular organism derive from a single ancestral cell, generally the fertilised egg cell. Phylodynamics provides a framework to analyse and model this data, by connecting the shared ancestry of cells in an organism to the cell population and tissue dynamics. By developing the mathematical and statistical foundations for the analysis of single cell data in a phylodynamic framework we will establish a powerful new computational tools for the analysis of tissues and developmental processes.

该项目生成了在发育系统和组织中观察单细胞数据所需的数学框架。多细胞生物体中的所有细胞都来自单一的祖先细胞，通常是受精卵细胞。系统动力学提供了一个框架来分析和建模这些数据，通过将生物体中细胞的共同祖先与细胞群和组织动力学联系起来。通过发展数学和统计基础的单细胞数据的分析，在一个动态的框架，我们将建立一个强大的新的计算工具的组织和发育过程的分析。