CellMaps for cell fate decision making systems

用于细胞命运决策系统的 CellMaps

• 批准号: FL220100005
• 负责人: Prof Michael Stumpf
• 金额: $ 231.18万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-02-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL220100005
• 关键词: CellMaps; cell; fate; decision; making

The cell is the fundamental unit exhibiting the hallmarks of life. The cell is also a fantastically intricate and complex system: its behaviour is shaped by molecular networks and processes that regulate cellular physiology, and the response of the cell to its environment. This Laureate Fellowship aims to describe and make sense of this complexity mathematically. At this sub-cellular level stochasticity and complex non-linear feedbacks are all pervasive. Building on recent advances in mathematics, statistics, theoretical physics, and data science will result in mathematical models of cells, CellMaps, that will generate mechanistic insights into the fundamental dynamical processes underlying cell fate decision making and differentiation.

细胞是展示生命特征的基本单位。细胞也是一个极其复杂的系统：它的行为是由调节细胞生理学的分子网络和过程以及细胞对其环境的反应所塑造的。这个获奖者奖学金的目的是描述和理解这种复杂性的数学。在这个亚细胞水平上，随机性和复杂的非线性反馈都是普遍存在的。基于数学、统计学、理论物理学和数据科学的最新进展，细胞的数学模型CellMaps将产生对细胞命运决策和分化的基本动力学过程的机械见解。