Behavioral and physiological research on a compensatory effect of enucleation and brain lesion in rats.

大鼠摘除和脑损伤代偿作用的行为和生理研究。

• 批准号: 09610085
• 负责人: IKEDA Yukinobu
• 金额: $ 2.05万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09610085/
• 关键词: black-white discrimination; albino rat; plasticity; enucleation; compensation; visual cortex; brain lesion; uncrossed optic pathways

In a previous study we investigated the effects of callosal transected lesions made 10 weeks earlier, either at 3 weeks of age or at 13 weeks of age, upon the acquisition of BW discrimination in rats either with one eye removed at birth (GEB) or in adulthood (OETs) following the CT visual cortex lesions. The CT visual lesions were perofrmed right before the training of BW discrimination. We found that the 10-week-old callosal transected lesions facilitated the acquisition in OEBs when the callosal lesions were given at 3 weeks of age, but not at 13 weeks of age, whereas the same type of callosal transected lesions did not do so in OETs, regardless of the age when the callosal lesions were made.Since the CT visual cortex lesions inevitably result in damage of the callosal neurons, and lead to degeneration of the callosal afferents in the IP visual cortex, the present study was undertaken to investigate if the 10-week-old CT visual cortex lesions, made at either 3 weeks of age or 13 weeks of age, would affect the acquisition of BW discrimination in OEBs and OETs, like the 10-week-old callosal transected lesions employed in the previous study mentioned above. We found that the facilitation effects generally tended to be more prevailing and pronounced : the 10-week-old CT visual cortex lesions made at 3 weeks of age facilitated the acquisition of BW discrimination not only in OEBs but also in OETs, and the same type of CT visual cortex lesions, made as late as 13 weeks of age, did so in OEBs but not in OETs. The findings are discussed in relation to the possible involvement of neurotrophic factors, released when the CT visual cortex lesions were made, in synaptic reorganization.

在之前的一项研究中，我们研究了在出生时或成年后进行CT视皮层损伤后，在出生时摘除一只眼睛(GEB)或成年后(OETS)，在10周前，无论是在3周龄还是在13周龄时进行的膝盖骨横断损伤，对大鼠获得体重辨别能力的影响。在BW辨别训练前进行CT视觉损害检查。我们发现，3周龄时，10周龄的胼胝体横断性病变促进了OeBS的习得，而13周龄的OETs则没有。由于CT视皮层病变不可避免地会导致胼胝体神经元的损伤，并导致IP视皮层内的胼胝体传入纤维变性，因此，本研究旨在探讨10周龄的CT视皮层病变，无论是在3周龄还是13周龄，会影响OeBS和OETs中BW歧视的获得，就像前面提到的先前研究中使用的10周大的膝盖骨横断性病变一样。我们发现，易化效应一般更普遍和更明显：10周龄的CT视皮层损伤在3周龄时不仅促进了OeBS的BW辨别能力，也促进了OETs的BW辨别能力；同样类型的CT视皮层损伤在13周龄的OeBS中也是如此，但在OETs中却没有。这些发现与神经营养因子可能参与突触重组有关，神经营养因子是在CT视皮层损伤时释放的。