Behavioral and physiological research on a compensatory effect of enucleation and brain lesion in rats.

在之前的一项研究中，我们研究了在CT视觉皮层病变后，出生时切除一只眼睛（GEB）或成年后切除一只眼睛（OETs）的大鼠，在3周龄或13周龄时切除10周胼胝体横断病变对获得BW辨别能力的影响。CT视觉病变在BW鉴别训练前进行。我们发现，10周大的胼胝体横切病变在3周龄时促进了OEBs的习得，而在13周龄时则没有，而相同类型的胼胝体横切病变在OETs中没有这样的作用，无论胼胝体病变形成的年龄。由于CT视觉皮层病变不可避免地导致胼胝体神经元的损伤，并导致IP视觉皮层胼胝体传入事件的变性，因此本研究将研究10周龄CT视觉皮层病变，无论是在3周龄还是13周龄，是否会像前文研究中使用的10周龄胼胝体横切病变一样，影响OEBs和oet的BW辨别获得。我们发现，促进效应通常更为普遍和明显：10周大的CT视觉皮层病变，在3周龄时形成，不仅促进了外型婴儿和外型婴儿辨别BW的习得，而同样类型的CT视觉皮层病变，在13周龄时形成，在外型婴儿中有促进作用，而在外型婴儿中没有。研究结果讨论了当CT视觉皮层病变时释放的神经营养因子可能参与突触重组。

In a previous study we investigated the effects of callosal transected lesions made 10 weeks earlier, either at 3 weeks of age or at 13 weeks of age, upon the acquisition of BW discrimination in rats either with one eye removed at birth (GEB) or in adulthood (OETs) following the CT visual cortex lesions. The CT visual lesions were perofrmed right before the training of BW discrimination. We found that the 10-week-old callosal transected lesions facilitated the acquisition in OEBs when the callosal lesions were given at 3 weeks of age, but not at 13 weeks of age, whereas the same type of callosal transected lesions did not do so in OETs, regardless of the age when the callosal lesions were made.Since the CT visual cortex lesions inevitably result in damage of the callosal neurons, and lead to degeneration of the callosal afferents in the IP visual cortex, the present study was undertaken to investigate if the 10-week-old CT visual cortex lesions, made at either 3 weeks of age or 13 weeks of age, would affect the acquisition of BW discrimination in OEBs and OETs, like the 10-week-old callosal transected lesions employed in the previous study mentioned above. We found that the facilitation effects generally tended to be more prevailing and pronounced : the 10-week-old CT visual cortex lesions made at 3 weeks of age facilitated the acquisition of BW discrimination not only in OEBs but also in OETs, and the same type of CT visual cortex lesions, made as late as 13 weeks of age, did so in OEBs but not in OETs. The findings are discussed in relation to the possible involvement of neurotrophic factors, released when the CT visual cortex lesions were made, in synaptic reorganization.