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Behavioral and physiological research on a compensatory effect for brain lesion in rats.

大鼠脑损伤代偿作用的行为和生理研究。

基本信息

批准号：
06610078
负责人：
IKEDA Yukinobu
金额：
$ 1.22万
依托单位：
Saga University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

项目摘要

A black-white discrimination task was given to two types of one-eyed rats at 3 months of age. One type had the right eye removed within 24 hours after brith (OEB). The other had the right eye enucleated at 3 months of age (OET). Both OEBs and OETs could learn the discrimination task at the same performance level. When the right visual cortex of the rats was lesioned and the same task was given to the subjects, OEBs could relearn the task significantly faster than OETs. It was considered that this effect was lead by reorganization of the optic pathways, especially of the uncrossed visual pathways.As it was seemed that an increased resolution capacity of uncrossed visual pathways in OEBs had an important role in the above mentioned effect, a horizontal-vertical discrimination task was employed to assess the levels of resolution capacity of OEBs and OETs. Both OEBs and OETs with their brain intact could acquire the discrimination between the stripes with a width of 30mm and relearn the task after the visual cortex contralateral to the remaining eye was lesioned. There was no difference in the relearning speed between the groups. Then, a width of stripes was gradually reduced ranging from 20mm to 5mm. It was found that the median width of the smallest stripes for OETs to discriminate was 10mm, and that of OEBs 7.5mm. Although OETs could not discriminate the smallest stripes which OEBs could, they were able to discriminate stripes one third smaller than those hypothesized. These findings suggested that our previously mentioned effect could not be explained only by resolution capacity. Cognition of the cue might be an important term upon the phenomenon. The approach to this problem is now undertaken in our laboratory.

在3月龄时，对两种类型的独眼大鼠进行黑白辨别任务。一种是在出生后24小时内摘除右眼（OEB）。另一只在3个月大时右眼摘除（OET）。OEBs和OEBs都可以在相同的绩效水平上学习辨别任务。当大鼠右侧视皮层受损并给予相同的任务时，OEBs的再学习速度明显快于OEBs。这种效应可能是由视通路的重组，特别是非交叉视通路的重组所引起的，由于OEB的非交叉视通路分辨能力的增强在上述效应中起着重要作用，因此采用水平-垂直辨别任务来评价OEB和OEB的分辨能力水平。大脑完整的OEBs和OEBs在损伤对侧视皮层后均能获得对30 mm宽条纹的辨别能力并重新学习任务。两组之间的再学习速度没有差异。然后，条纹的宽度逐渐减小，范围从20 mm到5 mm。结果表明，OEBs的最小条纹宽度中值为10 mm，OEBs的最小条纹宽度中值为7.5mm。虽然OEBs不能区分最小的条纹，OEBs可以，他们能够区分条纹的三分之一小于那些假设。这些发现表明，我们先前提到的效果不能仅用分辨率来解释。提示的认知可能是这一现象的一个重要术语。我们的实验室正在研究这个问题。