Recovery of localized brain function in learning disabled children -regional cerebral blood flow and cognitive-neuropsychological study-

学习障碍儿童局部脑功能的恢复-区域脑血流与认知-神经心理学研究-

基本信息

  • 批准号:
    09610161
  • 负责人:
  • 金额:
    $ 2.05万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1997
  • 资助国家:
    日本
  • 起止时间:
    1997 至 1999
  • 项目状态:
    已结题

项目摘要

Neuropsychological assessment batteries were used to detect higher brain dysfunction, and single photon emission tomography to measure regional cerebral blood flow (rCBF). 15 learning disabled (LD) children, with normal intellectual ability in psychological performance and no brain lesions detected by magnetic resonance imaging (MRI) or computed tomography, were examined from 1997 to 1999. They manifested specific cognitive disorders, namely, specific Kanji writing disorders, specific dyslexia with dysgraphia for Kanji, specific dyslexia with dysgraphia for both Kanji and Kana, and verbal semantic disorders. We supposed their dysfunction parts of their brain based on the place where rCBF is reduced compared with the contralateral area. Four of 15 children were evaluated twice for rCBF and cognitive neuropsychological abilities. As results, we found that the area with reduced rCBF in LD children correspond to the brain lesion in adults with an acquired brain damage showing similar symptoms. For example, all LD children who showed writing or reading disorders manifested reduced rCBF in their temporal and/or parietal lobe, and those showed verbal semantic disorders without non-verbal semantic disability, manifested reduced rCBF in their temporal lobe. These results suggest that LD is caused by a localized brain dysfunction.Two children showed almost no changes of their cognitive-neuropsychological symptoms. One had specific Kanji writing disorder and the other had dyslexia with dysgraphia for both of Kanji and Kana. Their rCBF showed almost no changes in the reduced rCBF for two years. On the other hand, a child, who manifested verbal semantic disorder, showed improvement in cognitive neuropsychological performance and rCBF in the left temporal lobe.Thus the change of cognitive neuropsychological performance and rCBF showed parallel in these LD children.
神经心理学评估电池用于检测高级脑功能障碍,单光子发射断层扫描用于测量区域脑血流量(rCBF)。本文从1997年至1999年对15例心理表现智力正常、核磁共振成像(MRI)或计算机断层扫描未发现脑损伤的学习障碍儿童进行了检查。他们表现出特定的认知障碍,即特定的汉字书写障碍,特定的阅读障碍伴汉字书写障碍,特定的阅读障碍伴汉字和假名书写障碍,以及言语语义障碍。我们根据rCBF相对于对侧区域减少的位置推测出他们大脑功能障碍的部分。对15名儿童中的4名进行两次rCBF和认知神经心理能力评估。结果,我们发现LD儿童rCBF减少的区域与表现出类似症状的获得性脑损伤成人的脑损伤相对应。例如,所有表现为写作或阅读障碍的LD儿童,其颞叶和/或顶叶rCBF均有所减少,而那些表现为言语语义障碍但无非言语语义障碍的LD儿童,其颞叶rCBF均有所减少。这些结果表明LD是由局部脑功能障碍引起的。两名儿童的认知神经心理症状几乎没有变化。其中一名患有特殊的汉字书写障碍,另一名患有汉字和假名的阅读障碍。他们的rCBF在两年内几乎没有变化。另一方面,表现出语言语义障碍的儿童在认知神经心理表现和左颞叶rCBF方面表现出改善。因此,认知神经心理表现和rCBF的变化在这些LD儿童中表现出平行的变化。

项目成果

期刊论文数量(36)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
春原則子,宇野彰,加我牧子,松田博史,金子真人: "Semantic-pragmatic disordersの一例における言語性の意味理解障害について-音韻処理過程と意味処理過程との乖離-"脳と発達. 31(4). 370-375 (1999)
Harukoriko、Akira Uno、Makiko Kaga、Hiroshi Matsuda、Masato Kaneko:“语义语用障碍示例中的语言语义理解障碍 - 语音和语义处理过程之间的分离 -” 31 (4)。 1999)
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    0
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Uno A, Haruhara N, Kaneko M, Kaga M, Matsuda H,: "Development of non-linguistic cognitive ability in specific language impairment children"The Japan Journal of Logopedics and Phoniatrics. 40. 388-392 (1999)
Uno A、Haruhara N、Kaneko M、Kaga M、Matsuda H,:“特定语言障碍儿童非语言认知能力的发展”日本语言外科和语音学杂志。
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    0
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Uno A, Kaga M, Inagaki M, Kaneko M, Haruhara N,: "Neurophysiological and neuropsychological development of cognition in a specific Kanji writing disabled child"Clinical Electroencephalography. 41(6). 392-396 (1999)
Uno A、Kaga M、Inagaki M、Kaneko M、Haruhara N,:“特定汉字书写障碍儿童认知的神经生理学和神经心理学发展”临床脑电图。
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    0
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Kaga M, Inagaki M, Uno A: "Language Disorder in Children"Ishiyaku shuppan. (in press). (2000)
加贺 M、稻垣 M、宇野 A:“儿童语言障碍”Ishiyaku shuppan。
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    0
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宇野彰、春原則子、金子真人、加我牧子、松田博史: "特異的言語機能障害児における非言語的認知能力の発達"音声言語医学. 40(4). 388-392 (1999)
Akira Uno、Ko Haruyori、Masato Kaneko、Makiko Kaga、Hiroshi Matsuda:“有特定语言障碍的儿童非语言认知能力的发展”,《言语和语言医学》40(4)。
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UNO Akira其他文献

UNO Akira的其他文献

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{{ truncateString('UNO Akira', 18)}}的其他基金

Clinical, computational and brain science study in developmental dyslexia especially for reading disorders
发育性阅读障碍(尤其是阅读障碍)的临床、计算和脑科学研究
  • 批准号:
    23330201
  • 财政年份:
    2011
  • 资助金额:
    $ 2.05万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
The study of development of screening test for pre-school children to detect children with learning disabilities to be, and efficacy of intervention for children with LD
学前儿童学习障碍筛查测试的开发及对学习障碍儿童的干预效果研究
  • 批准号:
    15300209
  • 财政年份:
    2003
  • 资助金额:
    $ 2.05万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
The Development of the Battery for Learning Disabled Children
学习障碍儿童电池的研制
  • 批准号:
    12610163
  • 财政年份:
    2000
  • 资助金额:
    $ 2.05万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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