Comparative study on precancerous lesions of liver cancer

肝癌癌前病变的对比研究

• 批准号: 08042013
• 负责人: KOJIRO Masamichi
• 金额: $ 4.61万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08042013/
• 关键词: liver cancer; premalignant lesion; hepatocellular carcinoma; dysplastic nodule; hapatitis virus; 肝硬変; 過形成結節; 腺腫様過形成; 異型腺腫様過形成

Hyper plastic nodular lesion (HNL) of liver cirrhosis has attracted both pathologists' and hepatologists' interests as a potential premalignant lesion of hepatocellular carcinoma (HOC). However, international diagnostic criteria are confused as well as its terminology. In the present study, we have performed a comparative study of HNL among Japanese and Canadian.Based on the histologic observation of the exchanged tissue slides of HNL from each side, we have almost reached to mutual agreement on diagnostic criteria, and have agreed to use "Dysplastic nodule" as international term for HNL.Eithty four percent of HOC bearing liver cirrhosis were hepatitis C virus (HCV)-related among Japanese cases, but the involvement of HCV and hepatitis B virus (HBV) was widely different among Asian and Caucasian Canadian cases. Namely, 87% of Asian Canadian cases were HBV-related, and 15% and 20% of Caucasian Canadians were HBV-related and HCV-related. In addition, 44% of Caucasian Canadian were heavy … More drinkers. Thus, it is inevitable to study the etiologic factors of HOC in North America according to racesw. As a close correlation between hepatocar cinogenesis and hepatitis viruses has been stressed, HOC was more prevalent among Asian Canadians with high HBV positivity.There was no significant difference in the prevalence of HNL among Japanese (14.1%) and Canadian (12.3%). But its prevalence was much higher in HCV-related cirrhosis both in Japanese and Canadian. HNL was only observed in HCV-related cases in Japanese, and was seen in 22.2% of HCV-related cases and in 10.2% of HBV-related cases among Canadian. The reason of such a high prevalence of HNL in HCV-related cirrhosis may be explained by that HCV-related cirrhosis consists of small regener ative nodules approximately 3mm in size and it is easier to detect HNL.In addition, the presence of consistent active inflammatory reaction in HCV-related cirrhosis may also attribute to high incidence of HNL as said to high incidence of HCC. Less

肝硬化的超塑性结节病变（HNL）作为一种潜在的肝细胞癌（HOC）前病变引起了病理学家和肝病学家的兴趣。然而，国际诊断标准及其术语都很混乱。在本研究中，我们对日本人和加拿大人的HNL进行了比较研究。根据双方交换的HNL组织切片的组织学观察，我们对HNL的诊断标准基本达成一致，并同意使用“发育不良结节”作为HNL的国际术语。在日本病例中，84%的HOC肝硬化与丙型肝炎病毒（HCV）相关，但在亚洲和加拿大高加索病例中，丙型肝炎病毒和乙型肝炎病毒（HBV）的参与程度有很大不同。也就是说，87%的亚裔加拿大人与hbv相关，15%和20%的高加索加拿大人与hbv相关和hcv相关。此外，44%的加拿大白人酗酒。因此，按种族研究北美地区HOC的病因是必然的。由于肝癌的发生与肝炎病毒密切相关，HOC在HBV高阳性的加拿大亚裔人群中更为普遍。日本（14.1%）和加拿大（12.3%）的HNL患病率无显著差异。但在日本和加拿大，其在丙型肝炎相关肝硬化中的患病率要高得多。HNL仅在日本hcv相关病例中观察到，在加拿大hcv相关病例中，HNL在22.2%的hcv相关病例和10.2%的hbv相关病例中观察到。HNL在丙型肝炎相关肝硬化中如此高的患病率可能是由于丙型肝炎相关肝硬化由约3mm大小的小再生结节组成，更容易发现HNL。此外，hcv相关肝硬化中持续存在的活动性炎症反应也可能归因于HNL的高发，正如HCC的高发一样。少