Immunohistochemical and molecular biological study on abnormality of adenomatous polyposis coli gene in oral cancer and premalignant lesion.

口腔癌及癌前病变中腺瘤性息肉病基因异常的免疫组织化学和分子生物学研究。

• 批准号: 07671962
• 负责人: TANZAWA Hideki
• 金额: $ 1.47万
• 依托单位: CHIBA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671962/
• 关键词: Oral cancer; premalignant lesion; leukoplakia; squamous-cell carcinoma; APC遺伝子; 口腔癌; 口腔; 癌抑制遺伝子; ヘテロ接合性消失(LOH)

Abnormalities of adenomatous polyposis coli (APC) gene have been detected in the gastric, esophageal and pancreatic carcinoma, and has been considered as a cause of the development of many malignant tumors derived from various glands. However, we reported that many abnormalities of APC gene were frequently detected in oral squamous-cell carcinoma and that APC gene must be one of the most significant genes for the oncogenesis of oral cancer. In this research, we revealed that abnormalities of APC gene are common events in the process of oncogenesis of oral cancer and that the incidence of them doesn't dependent on the primary site of tumor but on the differentiation level. According to our results, Clinical screening must be tried in near future.

大肠腺瘤性息肉病（APC）基因的缺失在胃癌、食管癌和胰腺癌中均有发现，并被认为是多种腺体恶性肿瘤发生的原因之一。然而，我们发现APC基因在口腔鳞状细胞癌中有许多异常，APC基因可能是口腔癌发生中最重要的基因之一。本研究揭示了APC基因异常是口腔癌发生过程中的常见事件，其发生率与肿瘤的原发部位无关，而与肿瘤的分化程度有关。根据我们的研究结果，临床筛查必须在不久的将来进行尝试。

项目成果

丹沢秀樹: "舌扁平上皮癌におけるAPC癌抑制遺伝子ヘラロ接合性消欠の検索" 日本口腔外科学会誌. 41. 191-194 (1995)

Hideki Tanzawa：“寻找舌鳞状细胞癌中的 APC 肿瘤抑制基因杂合缺失”日本口腔颌面外科杂志 41. 191-194 (1995)。

丹沢秀樹: "口腔悪性腫瘍におけるAPC癌抑制遺伝子異常の検索" 頭頸部腫瘍. 21. 13-15 (1995)

Hideki Tanzawa：“寻找口腔恶性肿瘤中的 APC 肿瘤抑制基因异常”头颈肿瘤。 21. 13-15 (1995)

丹沢秀樹: "舌扁平上皮癌におけるAPC癌抑制遺伝子ヘテロ接合性消失の検索" 日本口腔外科学会誌. 41. 191-194 (1995)

Hideki Tanzawa：“寻找舌鳞状细胞癌中 APC 肿瘤抑制基因杂合性的丢失”日本口腔颌面外科杂志 41. 191-194 (1995)。

Hideki Tanzawa: "Detection of abnormality of adenomatous polyposis coli gene in oral malignant tumors." Head and Neck Cancer. 21. 13-16 (1995)

Hideki Tanzawa：“口腔恶性肿瘤中腺瘤性息肉病大肠杆菌基因异常的检测”。

丹沢 秀樹: "舌扁平上皮癌におけるAPC癌抑制遺伝子ヘテロ接合性消失の検索" 日本口腔外科学会雑誌. 41. 191-194 (1995)

Hideki Tanzawa：“寻找舌鳞状细胞癌中 APC 肿瘤抑制基因杂合性的丢失”日本口腔颌面外科杂志 41. 191-194 (1995)。