Single crystal diffractometer

单晶衍射仪

• 批准号: 527802652
• 金额: --
• 依托单位: Rheinisch-Westfälische Technische Hochschule Aachen
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/527802652?language=en
• 关键词: Single; crystal; diffractometer

Single-crystal X-ray diffraction is one of the most powerful analytical methods for the structure elucidation of organic molecules. This valuable technique provides direct information on the types of atoms, their linkage and spatial arrangement in molecules. The characterization of new and structurally complex chemicals is often not possible without the use of modern X-ray diffraction methods. The Institute of Organic Chemistry (IOC) at RWTH operates a 14-year-old diffractometer, which is, due to recurring technical issues and defects, not able to support the research activities of the researchers working in the IOC. The diffractometer requested in this application will replace the old one and provide modern X-ray analytical facilities which are vital to assist the research conducted in the IOC. This device will support all IOC research groups in advancing their cutting-edge research programs and continue the work currently funded by, for example, the DFG, the Volkswagen Foundation and the ERC Horizon 2020 Framework. The research work conducted in the IOC is very diverse, spanning a wide variety of directions, which raises different analytical needs. The analysis of air and temperature sensitive organometallic species and supramolecular aggregates as well as the determination of the absolute configuration of complex chiral molecules are all aspects that can often be addressed only using modern X-ray diffraction techniques. In this application, we are requesting a single-crystal X-ray diffractometer equipped with a double copper and molybdenum radiation sources and a temperature control unit. The copper-radiation system will be essential for the analysis of chiral organic compounds consisting only of light atoms (e.g. C, H, O, N) as it offers direct access to the correct stereochemical configuration without having to resort to additional chemical modifications (e.g. derivatization to form diastereomers). This technique will also enable the analysis of poorly or weakly scattering crystals as well as crystals with large unit cells. The molybdenum source will also be crucial as it enables fast measurements required for the analysis of sensitive organometallic complexes and chiral organic compounds containing heavy atoms. Since many organic compounds are thermally labile, it is crucial to be able to run these analyses at low temperature. This means that further technical requirements need to be considered to address all the IOC’s analytical needs. In summary, with this application we request a powerful and easy to maintain 4-circle single-crystal diffractometer equipped with a modern pixel detector, two microfocus sources, a cooling unit and a user-friendly software. This instrument will be a strategic addition to the IOC core facilities and will allow all research groups to continue their work in a globally competitive environment equipped with cutting-edge technology.

单晶X射线衍射是有机分子结构解析的最有力的分析方法之一。这种有价值的技术提供了关于原子类型、它们在分子中的连接和空间排列的直接信息。如果不使用现代X射线衍射方法，新的和结构复杂的化学品的表征往往是不可能的。RWTH的有机化学研究所（IOC）使用了一台14年的衍射仪，由于经常出现的技术问题和缺陷，无法支持在IOC工作的研究人员的研究活动。此次申请中所要求的衍射仪将取代旧的衍射仪，并提供现代化的X射线分析设施，这对协助IOC进行的研究至关重要。该设备将支持所有国际奥委会研究小组推进其尖端研究计划，并继续开展目前由DFG、大众汽车基金会和ERC Horizon 2020框架等资助的工作。在政府间海洋学委员会进行的研究工作非常多样化，涉及各种各样的方向，这就提出了不同的分析需求。对空气和温度敏感的有机金属物种和超分子聚集体的分析以及复杂手性分子的绝对构型的测定都是通常只能使用现代X射线衍射技术来解决的方面。在此应用中，我们需要一台单晶X射线衍射仪，配备铜和钼双辐射源以及温度控制单元。铜辐射系统对于分析仅由轻原子（例如C、H、O、N）组成的手性有机化合物是必不可少的，因为它提供了直接获得正确的立体化学构型的途径，而不必求助于额外的化学修饰（例如衍生化以形成非对映异构体）。这种技术也将使差或弱散射晶体以及具有大晶胞的晶体的分析成为可能。钼源也将是至关重要的，因为它可以实现分析敏感的有机金属络合物和含有重原子的手性有机化合物所需的快速测量。由于许多有机化合物是热不稳定的，因此能够在低温下进行这些分析至关重要。这意味着需要考虑进一步的技术要求，以满足国际奥委会的所有分析需求。总之，对于该应用，我们需要一台功能强大且易于维护的4圆单晶衍射仪，配备现代像素检测器、两个微焦点光源、冷却装置和用户友好的软件。该仪器将是对国际奥委会核心设施的战略性补充，并将使所有研究小组能够在配备尖端技术的全球竞争环境中继续开展工作。