PREPARATION OF BIOMATERIAL ON AMORPHOUS CALCIUM PHOSPHATE AND PROTEIN COMPOSITES

研究了以无定形磷酸钙和蛋白为复合材料制备生物材料的方法。(1)无定形磷酸钙晶体膜的组成与结构：采用140℃高压灭菌器热处理20小时，合成了无定形磷酸钙晶体膜。(2)组成物的离子交换性质改变了无定形磷酸钙，其结晶组成改变了磷灰石被CO_3^<2->或SiO_4^<4->取代，羟基磷灰石结构中的部分PO_4^<3->同时交换了有害的正离子和阴离子，有望作为环境净化材料。(3)凝胶体系沉淀空心纤维状羟基磷灰石，将含有Ca^<2+>离子的液体溶液和羟基磷灰石加入含有PO_4^<3->离子的凝胶中，合成空心纤维状羟基磷灰石。(4)以无定形磷酸钙为原料沉淀磷灰石硬化体加入经酸处理的白云石溶液，在60-100‰的温度下也可形成无定形磷酸钙。无定形磷酸钙在加热条件下易结晶，其结构β - tcp比α - tcp更稳定，水化硬化程度降低。(5)在无定形磷酸钙和蛋白复合材料上制备植入材料。将无定形磷酸钙浸在含白蛋白的林格氏溶液中，与羟基磷灰石色谱相比，结晶磷酸钙吸附白蛋白的量大。(6)含二价金属离子的非晶态磷酸钙在液中的稳定性各加入二价金属离子均提高了非晶态磷酸钙的稳定性，证明在液中羟基磷灰石的转化反应得到控制。

Preparation of biomaterial on amorphous calcium phosphate and protein composites was investigated by separated to team of six.(1)Composition and structure of amorphous calcium phosphateHAp crystal film was synthesized by thermaltreated using autoclave apparatus 140ﾟC for 20 hours.(2)Ion exchange property of composition changed amorphous calcium phosphate and its crystallineCompositions changed apatite substituted with CO_3^<2-> or SiO_4^<4-> a part of PO_4^<3-> in hydroxyapatite structure was promising as environment purify materials which was exchanged at the same time harmful cation and anion ion.(3)Precipitation of hollow fibrous hydroxyapatite using gel systemHollow fibrous hydroxyapatite was synthesized by adding liquid solution included Ca^<2+> ion and hydroxyplopileselroce to gel included PO_4^<3-> ion.(4)Precipitation of apatite hardened body using amorphous calcium phosphate as starting materialAmorphous calcium phosphate was also formed at 60-100ﾟC by adding acid-treated solution of dolomite. When amorphous calcium phosphate was heated, it crystallized easily more stability of structure beta-TCP than alpha-TCP and was decreased hydration harden.(5)Preparation of implant material on amorphous calcium phosphate and protein compositesThe resulting of dipping amorphous calcium phosphate in ringer solution including albumin, amount of albumin adsorbed on crystallized HAp was large compared with hydroxyapatite forion chromatograph.(6)Stability of divalent metal ion-containing amorphous calcium phosphate in liquor Stability of amorphous calcium phosphate by adding each divalent metal ion was increased, and it was evidenced that conversion reaction to hydroxyapatite in liquor controlled.