PREPARATION OF BIOMATERIAL ON AMORPHOUS CALCIUM PHOSPHATE AND PROTEIN COMPOSITES

研究了生物材料在无定形磷酸钙/蛋白质复合材料上的制备。(1)利用140ﾟC高压反应装置热处理20小时，合成了非晶态磷酸钙晶体薄膜的组成和结构。(2)组成改变了非晶态磷酸钙的离子交换性能及其晶体组成改变了磷灰石被CO_3^&lt；2-&gt；或SiO_4^&lt；4-&gt；部分PO_4^&lt；3-&gt；用凝胶体系沉淀中空纤维羟基磷灰石是一种很有前途的环境净化材料。(3)用凝胶体系沉淀中空纤维羟基磷灰石。在凝胶中加入含Ca~(2+)~(2+)离子的液体溶液和含有PO_4~(2+)~(3-)离子的羟基磷灰石合成了中空纤维羟基磷灰石。(4)以无定形磷酸钙为原料，在60~100ﾟC加入白云石酸处理溶液，也可得到无定形的无定形磷酸钙。非晶态磷酸钙在受热条件下，比α-磷酸三钙更容易结晶，结构更加稳定，水化硬化程度降低。(5)非晶态磷酸钙和蛋白质复合体的制备将非晶态磷酸钙浸泡在含有白蛋白的环形溶液中，与羟基磷灰石柱层析仪相比，晶态磷酸钙上的白蛋白吸附量较大。(6)含二价金属离子的无定形磷酸钙在溶液中的稳定性通过加入各二价金属离子提高了无定形磷酸钙的稳定性，证明了溶液中向羟基磷灰石的转化反应受控。

Preparation of biomaterial on amorphous calcium phosphate and protein composites was investigated by separated to team of six.(1)Composition and structure of amorphous calcium phosphateHAp crystal film was synthesized by thermaltreated using autoclave apparatus 140ﾟC for 20 hours.(2)Ion exchange property of composition changed amorphous calcium phosphate and its crystallineCompositions changed apatite substituted with CO_3^<2-> or SiO_4^<4-> a part of PO_4^<3-> in hydroxyapatite structure was promising as environment purify materials which was exchanged at the same time harmful cation and anion ion.(3)Precipitation of hollow fibrous hydroxyapatite using gel systemHollow fibrous hydroxyapatite was synthesized by adding liquid solution included Ca^<2+> ion and hydroxyplopileselroce to gel included PO_4^<3-> ion.(4)Precipitation of apatite hardened body using amorphous calcium phosphate as starting materialAmorphous calcium phosphate was also formed at 60-100ﾟC by adding acid-treated solution of dolomite. When amorphous calcium phosphate was heated, it crystallized easily more stability of structure beta-TCP than alpha-TCP and was decreased hydration harden.(5)Preparation of implant material on amorphous calcium phosphate and protein compositesThe resulting of dipping amorphous calcium phosphate in ringer solution including albumin, amount of albumin adsorbed on crystallized HAp was large compared with hydroxyapatite forion chromatograph.(6)Stability of divalent metal ion-containing amorphous calcium phosphate in liquor Stability of amorphous calcium phosphate by adding each divalent metal ion was increased, and it was evidenced that conversion reaction to hydroxyapatite in liquor controlled.