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PREPARATION OF BIOMATERIAL ON AMORPHOUS CALCIUM PHOSPHATE AND PROTEIN COMPOSITES

无定形磷酸钙与蛋白质复合生物材料的制备

基本信息

批准号：
08305035
负责人：
ARAI Yasuo
金额：
$ 6.59万
依托单位：
NIHON UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

项目摘要

Preparation of biomaterial on amorphous calcium phosphate and protein composites was investigated by separated to team of six.(1)Composition and structure of amorphous calcium phosphateHAp crystal film was synthesized by thermaltreated using autoclave apparatus 140ﾟC for 20 hours.(2)Ion exchange property of composition changed amorphous calcium phosphate and its crystallineCompositions changed apatite substituted with CO_3^<2-> or SiO_4^<4-> a part of PO_4^<3-> in hydroxyapatite structure was promising as environment purify materials which was exchanged at the same time harmful cation and anion ion.(3)Precipitation of hollow fibrous hydroxyapatite using gel systemHollow fibrous hydroxyapatite was synthesized by adding liquid solution included Ca^<2+> ion and hydroxyplopileselroce to gel included PO_4^<3-> ion.(4)Precipitation of apatite hardened body using amorphous calcium phosphate as starting materialAmorphous calcium phosphate was also formed at 60-100ﾟC by adding acid-treated solution of dolomite. When amorphous calcium phosphate was heated, it crystallized easily more stability of structure beta-TCP than alpha-TCP and was decreased hydration harden.(5)Preparation of implant material on amorphous calcium phosphate and protein compositesThe resulting of dipping amorphous calcium phosphate in ringer solution including albumin, amount of albumin adsorbed on crystallized HAp was large compared with hydroxyapatite forion chromatograph.(6)Stability of divalent metal ion-containing amorphous calcium phosphate in liquor Stability of amorphous calcium phosphate by adding each divalent metal ion was increased, and it was evidenced that conversion reaction to hydroxyapatite in liquor controlled.

采用六人一组的方法，研究了无定形磷酸钙/蛋白质复合生物材料的制备。（1）采用高压釜140 ℃热处理20小时，制备了无定形磷酸钙HAp晶体薄膜。（2）组成改变后的无定形磷酸钙及其晶体的离子交换性能组成改变后的磷灰石，其结构中的部分PO_4 ~+被CO_3 ~+<2->或SiO_4 ~+<4-><3->取代，可同时交换有害的阳离子和阴离子，是一种很有前途的环境净化材料。（3）凝胶体系制备中空纤维羟基磷灰石的研究将含Ca ~（2+）离子和羟基磷灰石的溶液加入到含PO_4 ~（2+）离子的凝胶体系中，制备出中空纤维羟基磷灰石<3->。（4）以无定形磷酸钙为起始原料的磷灰石硬化体的析出加入白云石的酸处理溶液，在60-100 ℃下也可形成无定形磷酸钙。无定形磷酸钙在加热条件下更容易结晶，其结构稳定性比α-TCP好，水化硬化程度降低。（5）无定形磷酸钙/蛋白复合材料植入材料的制备无定形磷酸钙浸泡于含白蛋白的林格液中，与离子色谱法测定的羟基磷灰石相比，结晶后的羟基磷灰石对白蛋白的吸附量较大。（6）含二价金属离子的无定形磷酸钙在液体中的稳定性通过添加每种二价金属离子，无定形磷酸钙的稳定性增加，并且证明在液体中控制了向羟基磷灰石的转化反应。