Tuning mesenchymal stem cell lifespan, performance, and differentiation

调节间充质干细胞的寿命、性能和分化

• 批准号: DP220101644
• 负责人: Dr Giselle Yeo
• 金额: $ 40.93万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101644
• 关键词: Tuning; mesenchymal; stem; cell; lifespan

This project aims to fully characterise a unique molecular process that strongly modulates mesenchymal stem cell lifespan and behaviour. This work is significant, as it is expected to reveal new concepts underpinning the mechanistic actions of classical structural proteins. It will also shape a more nuanced understanding of the context-dependent mechanical and biochemical signals that regulate stem cell fate and function. Expected outcomes include new knowledge surrounding native extracellular matrix and stem cell biology, and the development of strategies to define and tailor stem cell properties. This work is anticipated to drive new technologies that can efficiently and robustly manipulate stem cells for diverse functional applications.

该项目旨在充分研究一种独特的分子过程，该过程强烈调节间充质干细胞的寿命和行为。这项工作意义重大，因为它有望揭示支持经典结构蛋白质机制作用的新概念。它还将塑造一个更微妙的理解的上下文依赖的机械和生化信号，调节干细胞的命运和功能。预期成果包括围绕天然细胞外基质和干细胞生物学的新知识，以及定义和定制干细胞特性的策略的发展。这项工作预计将推动新技术，可以有效和强大地操纵干细胞用于各种功能应用。