Biomechanical and Histologic analysis of artificial intervertebral disc replacement under dynamic in vivo environment.

本研究的目的是在动物模型中分析人工全椎间盘置换术的节段生物力学和界面组织学。一种新型人工椎间盘由超高分子量聚乙烯纤维编织的三轴三维织物和喷涂在椎间盘表面的生物活性陶瓷组成。从1996年开始，对人工盘的基本结构进行了设计。它代表了与正常腰椎间盘相似的拉压、扭转、粘弹性和疲劳特性。全椎间盘置换术在绵羊模型中进行，观察期为15个月。使用生物可吸收的内固定装置，在15个月时安全地实现了人工椎间盘的初始固定，并保持了三维节段活动。组织学上，椎小梁与人工椎间盘直接接触，插入人工椎间盘内部组织。分离试验检测的界面强度超过了先前报道的陶瓷界面强度。采用生物可吸收性脊柱固定的人工全椎间盘置换术在未来的脊柱重建中具有潜在的应用价值。

The objective of this study was to analyze the segmental biomechanics and interface histology of the total artificial intervertebral disc replacement in an animal model. A new artificial intervertebral disc consisted of a triaxial three-dimensional fabric woven by an ultrahigh molecular weight polyethylene fiber, and spray-coated bioactive ceramics on the disc surface. From 1996, the basic structure of artificial disc has been designed. It represented the tensile-compressive, torsional, viscoelastic, and fatigue properties similar to the normal lumbar disc. The total intervertebral disc replacement was conducted in a sheep model with the observation periods up to 15 months. Using a bioabsorbable internal fixation device, the initial fixation of artificial disc was securely achieved and three-dimensional segmental mobility was preserved at 15 months. Histologically, the vertebral trabeculae showed a direct contact to artificial disc, inserting into the fabric inside. The interface strength examined by detaching tests exceeded the ones of ceramic interface, which were previously reported. The total artificial disc replacement using bioabsorbable spinal fixation has a potential for the future spinal reconstruction.