Biomechanical and Histologic analysis of artificial intervertebral disc replacement under dynamic in vivo environment.

动态体内环境下人工椎间盘置换的生物力学和组织学分析。

• 批准号: 08407045
• 负责人: KANEDA Kiyoshi
• 金额: $ 26.05万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08407045/
• 关键词: ARTIFICIAL DISC; BIOMECHANICS; SPlNE; BIOCERAMICS

The objective of this study was to analyze the segmental biomechanics and interface histology of the total artificial intervertebral disc replacement in an animal model. A new artificial intervertebral disc consisted of a triaxial three-dimensional fabric woven by an ultrahigh molecular weight polyethylene fiber, and spray-coated bioactive ceramics on the disc surface. From 1996, the basic structure of artificial disc has been designed. It represented the tensile-compressive, torsional, viscoelastic, and fatigue properties similar to the normal lumbar disc. The total intervertebral disc replacement was conducted in a sheep model with the observation periods up to 15 months. Using a bioabsorbable internal fixation device, the initial fixation of artificial disc was securely achieved and three-dimensional segmental mobility was preserved at 15 months. Histologically, the vertebral trabeculae showed a direct contact to artificial disc, inserting into the fabric inside. The interface strength examined by detaching tests exceeded the ones of ceramic interface, which were previously reported. The total artificial disc replacement using bioabsorbable spinal fixation has a potential for the future spinal reconstruction.

本研究的目的是在动物模型上分析人工全椎间盘置换的节段生物力学和界面组织学。一种新型的人工椎间盘由一种高分子量聚乙烯纤维编织的三轴三维织物和喷涂在椎间盘表面的生物活性陶瓷组成。从1996年开始，设计了人工椎间盘的基本结构。其拉伸-压缩、扭转、粘弹性和疲劳性能与正常腰椎间盘相似。在绵羊模型上进行全椎间盘置换术，观察期长达15个月。使用生物可吸收内固定装置，人工椎间盘的初始固定是安全的，并在15个月时保留了三维节段活动度。组织学上，椎骨小梁与人工椎间盘直接接触，插入内部织物中。剥离试验检测的界面强度超过了以前报道的陶瓷界面强度。生物可吸收脊柱内固定的全人工椎间盘置换术是未来脊柱重建的一种潜在方法。

项目成果

小谷喜久他: "全置換型人工椎間板の開発と臨床応用の展望"臨床整形外科. 35. 575-580 (2000)

Yoshihisa Kotani 等人：“全置换人工椎间盘的开发和临床应用前景”《临床骨科》35. 575-580 (2000)。

高畑雅彦他: "人工椎間板と椎体の界面強度に関する生体力学的検討"臨床整形外科. (印刷中). (2000)

Masahiko Takahata 等：“人工椎间盘与椎体之间界面强度的生物力学研究”《临床骨科》（2000 年出版）。

Shikinami, Y: "Potential application of a triaxial three-dimensional fabric (3-DF) as an implant/"Biomaterials. 19. 617-635 (1998)

Shikinami, Y：“三轴三维织物 (3-DF) 作为植入物的潜在应用/”生物材料。

Kotani, Y.: "Development of three-dimensional fabric disc and animal study of total intervertebral disc replacement."12ィイD1thィエD1 Japan Bioengineering meeting. 97-98 (1999)

Kotani, Y.：“三维织物椎间盘的开发和全椎间盘置换的动物研究。”12D1D1 日本生物工程会议 97-98 (1999)。

Kotani, Y.: "Biomechanical and Histological evaluation of total intervertebral disc replacement using triaxial three-dimensional fabric."Journal of Japan Clinical Biomechanics. 20. 13-18 (1999)

Kotani, Y.：“使用三轴三维织物进行全椎间盘置换的生物力学和组织学评估。”日本临床生物力学杂志。