Reserch on Spinal Reconstruction for Malignant Spinal Tumors and Development of Biomaterials and Spinal Instrumentation

脊柱恶性肿瘤的脊柱重建研究及生物材料和脊柱器械的开发

• 批准号: 63480336
• 负责人: KANEDA Kiyoshi
• 金额: $ 2.5万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63480336/
• 关键词: Malignant spinal tumor; Spinal reconstruction; Biomaterials; Bioactive ceramic; Spinal Instrumentation; Kaneda device; 脊柱再建術; 脊椎インストルメンテ-ション; 脊椎内固定具; 椎体置換

Computational simulation of the whole lumbar spine under flexionComputational simulation of the whole lumbar spine under flexion were carried out using the element model. As a result, in flexion at constant moment ,the stress distributions of five intervertebral discs in the lumbar spine are almost the same. On the other hand, at shear force, the stress of discs in the lower lesion are higher.2 Biomechanical evaluation of spinal fixation deviceThe three-dimentional stability provided by six spinal fixation devices has been studied in an in vitro biomechanical model using five-vertebral (Tll-L3) fresh cadaveric thoracolumbar specimens. An injury was created at T12-L1 by complete transection of the posterior elements and posterior half of of the intervertebral disc. External skeletal fixation was the only device that provided sufficient stability for thoracolumbar posterior injury model for all load types. The Kaneda device with transverse fixators was the next most stable instrumentatio … More n.3 Experimental study of vertebral replacement with A-WGC vertebral spacer and anterior instrumentationWe prepared a artificial vertebral spacer for the replacement of the lumbar vertebral of dog, using apatite-and wollastonite-containing glass-ceramic (A-W. GC). Five dogs underwent replacement of a whole vertebral body with A-WGC vertebral spacer. The animals were killed at intervals from six months to 14 months after operation, and the interface between A-WGC and bone was examined radiolpgically and histologically. Bone bonding with A-WGC had not occurred. More rigid fixation of the A-WGC vertebral spacer is required for bonding to bone.4 Anterior spinal reconstruction for the metastatic patients, using A-WGC vertebral spacer and Kaneda deviceSix patients suffering from matastatic spinal tumor were treated with A-WGC vertebral spacer and Kaneda device. The rates of positive recovery were as follows : 100% for pain relief, and 100% for neurologic recovery. Patients suffering from severe pain and spinal cord and/or nerve root compression benefited from this surgery. Less

全腰椎屈曲的计算模拟采用单元模型对全腰椎屈曲进行了计算模拟。因此，在恒定力矩屈曲时，腰椎5个椎间盘的应力分布几乎相同。另一方面，在剪切力作用下，下病变处椎间盘的应力较大在体外生物力学模型中研究了六种脊柱固定装置提供的三维稳定性，该模型使用五椎体（Tll-L3）新鲜尸体胸腰椎标本。在T12-L1处通过完全横断后部构件和椎间盘后半部分造成损伤。对于所有负荷类型的胸腰椎后路损伤模型，骨外固定架是唯一能够提供足够稳定性的装置。带横向固定架的Kaneda器械是第二稳定的器械a - wgc椎体垫片和前路内固定的实验研究我们用含磷灰石和硅灰石的玻璃陶瓷（a - w）制备了一种人工椎体垫片用于犬腰椎置换术。GC)。5只狗用a - wgc椎体垫片置换了整个椎体。术后6 ~ 14个月处死动物，对A-WGC与骨的界面进行放射学和组织学检查。未发生与A-WGC的骨结合。A-WGC椎间垫需要更坚固的固定以与骨结合采用A-WGC椎间垫和金田装置对转移性脊柱肿瘤进行前路重建。阳性恢复率：疼痛缓解100%，神经功能恢复100%。患有严重疼痛和脊髓和/或神经根压迫的患者受益于该手术。少

项目成果

山元 功: "有限要素法による全腰椎動態解析" 整形外科バイオメカニクス. 11. 17-19 (1989)

Isao Yamamoto：“使用有限元方法进行全腰椎动态分析”骨科生物力学。11. 17-19 (1989)

但野 茂: "全腰椎の前方屈曲シミュ-レ-ション" 日本機械学会論文集. 56. 1885-1892 (1990)

Shigeru Tadano：“整个腰椎向前弯曲的模拟”日本机械工程师学会汇刊 56。1885-1892（1990）。

金田 清志: "脊椎再建術の進歩" オペナ-シング. 6. 29-35 (1991)

Kiyoshi Kaneda：“脊柱重建的进展”开篇。6. 29-35 (1991)。

S. Shirado: "Radiographic and biomechanical study of anterior spinal reconstructive surgery following corpectomy in a canine model." Proceedings of 1989 annual meeting of Jap. society for orthop. biomechanics. 11. 25-29 (1989)

S. Shirado：“犬模型椎体切除术后前路脊柱重建手术的放射学和生物力学研究。”

S. Tadano: "Simulation of the whole lumbar spine in forward flexion" Jour. JSME. 56. 1885-1892 (1990)

S. Tadano：“整个腰椎向前屈曲的模拟”Jour。