Development of artificial intervertebral disc and artificial nucleus pulposus

人工椎间盘和人工髓核的研制

• 批准号: 02557055
• 负责人: KANEDA Kiyoshi
• 金额: $ 11.52万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02557055/
• 关键词: human lumbar intervertebral disc; artificial intervertebral disc; artificial nucleus pulposus; bioactive ceramics; biocompatible elastomer

(1) Evaluation of the mechanical properties of the human L4-5 functional spinal unit during cyclic loading : Cyclic axial compression-tension tests and cyclic torsional tests were performed on ten fresh human L4-5 functional spinal units to investigate the structural effects of the posterior elements of L4-5 functional spinal units.The stiffness of the functional spinal unit increased with increase of displacement under every loading, This was same in the intact functional spinal units and the functional spinal units after removal each posterior element, respectively. All the posterior elements contributed to the compressive, tensile, and torsional stiffness of L4-5 functional spinal units. The apophyseal joints had a significant effect on the compressive and torsional stiffness. The effect of the apophyseal joints on the torsional stiffness became greater according to the extent of displacement, whereas their effect on the compressive stiffness was constant. The posterior ligaments (s … More upraspinous and interspinous ligaments) had a significant effect on the tensile stiffness.(2) Evaluation of the mechanical properties of the human L4-5 disc during cyclic loading : Ten fresh human L4-5 disc-body units (DBUs) were examined for investigation of the relationship between the stiffness properties of L4-5 intervertebral disc and the displacement by cyclic compression-tension and torsion tests. The effects of an injury to the anulus fibrosus, nucleotomy and the filling-up of the denucleated space with silicone elastomer on the stiffness properties of L4-5 disc were also investigated.The stiffness of L4-5 intervertebral disc increased with the increase of displacement in every type of loading, In each type of loading, the stiffness of the intervertebral disc after nucleotomy decreased significantly in every region of displacement. The torsional stiffness was restored significantly by the filling-up of the denucleated space with silicone elastomer. However, there was little restoration of both the compressive and tensile stiffness.(3) Structural design of an artificial intervertebral disc : A new artificial intervertebral disc is proposed to reconstruct the stability and mobility of a human functional spinal unit. The geometry and the structure of the artificial intervertebral disc were designed by the computer simulation at 3D-FEM, as the compressive and the torsional stiffness of this model agree with the stiffness of cadaveric lumbar discs.Consequently, the proposed model consists of two bioactive ceramic plates and intervenient substructure made from rubber-like materials. Glass-ceramic containing apatite and wollastonite was chosen as a material for the plates which come into contact with the bone, because this material is able to form a strong chemical bond with the osseous tissue. Elastic materials of medical grade in the substructure between two plates were selected, as a the artificial disc has the same stiffness properties with a cadaveric lumbar disc. Less

(1) 人体L4-5功能性脊柱单元在循环加载过程中的力学性能评价：对10个新鲜的人体L4-5功能性脊柱单元进行循环轴向压缩拉伸试验和循环扭转试验，以研究L4-5功能性脊柱单元后部元件的结构效应。功能性脊柱单元的刚度随着每次加载下位移的增加而增加，这与 分别为完整的功能性脊柱单元和移除每个后部元件后的功能性脊柱单元。所有后部元件都对 L4-5 功能性脊柱单元的压缩、拉伸和扭转刚度做出了贡献。骨突关节对压缩刚度和扭转刚度有显着影响。骨突关节对扭转刚度的影响随着位移的程度而变大，而它们对压缩刚度的影响是恒定的。后韧带（棘上韧带和棘间韧带）对拉伸刚度有显着影响。（2）循环加载期间人体L4-5椎间盘的力学性能评估：检查了10个新鲜的人体L4-5椎间盘体单元（DBU），以研究L4-5椎间盘的刚度性能与循环位移之间的关系 压缩-拉伸和扭转测试。还研究了纤维环损伤、髓核切除和硅酮弹性体填充去核间隙对L4-5椎间盘刚度特性的影响。在每种类型的加载中，L4-5椎间盘的刚度随着位移的增加而增加，在每种类型的负载中，髓核切除后椎间盘的刚度在各区域均显着下降。 位移。通过用有机硅弹性体填充去核空间，扭转刚度显着恢复。然而，压缩刚度和拉伸刚度几乎没有恢复。(3)人工椎间盘的结构设计：提出了一种新的人工椎间盘来重建人体功能性脊柱单元的稳定性和活动性。人工椎间盘的几何形状和结构是通过 3D-FEM 计算机模拟设计的，因为该模型的压缩刚度和扭转刚度与尸体腰椎间盘的刚度一致。因此，该模型由两块生物活性陶瓷板和由橡胶类材料制成的中间子结构组成。选择含有磷灰石和硅灰石的玻璃陶瓷作为与骨接触的板的材料，因为这种材料能够与骨组织形成牢固的化学键。两块板之间的下部结构选择了医用级弹性材料，因为人造椎间盘具有与尸体腰椎间盘相同的刚度特性。较少的

项目成果

但野 茂: "人工椎間板の構造検討." 整形外科バイオメカニクス. 13. 75-79 (1992)

Shigeru Tadano：“人工椎间盘的结构研究。”13. 75-79 (1992)

Satoshi Asano, et al: "The structural effects of the posterior elements on the mechanical properties of the human lumbar (L4-5) functional spinal unit during cyclic loading." Proceedings of 7th International Conference on Biomedical Engineering.237-239 (1

Satoshi Asano 等人：“循环加载期间后部元件对人体腰椎 (L4-5) 功能性脊柱单元机械性能的结构影响。”

但野 茂: "ヒト腰椎椎間板の剛性特性." 日本機械学会第2回バイオエンジニアリングシンポジウム講演論文集. 920(7). 61-62 (1992)

Shigeru Tadano：“人体腰椎间盘的硬度特性。”日本机械工程师学会第二届生物工程研讨会论文集 920(7) (1992)。

SATOSHI ASANO: "A NEW DESIGN FOR THE ARTIFICIAL INTERVERTEBRAL CISC" Abstracts of The First World Congress of Biomechanics. I. 159 (1990)

SATOSHI ASANO：“人工椎间 CISC 的新设计”第一届世界生物力学大会摘要。

但野 茂: "ヒト腰椎椎間板の剛性曲線に及ぼす髄核の影響." 日本機械学会第4回バイオエンジニアリング部門学術講演会講演論文集. 920(64). 117-119 (1992)

Shigeru Tadano：“髓核对人体腰椎间盘硬度曲线的影响”，日本机械工程学会第四届生物工程分会学术会议记录 920(64)（1992）。