Pathogenesisi of anemia induced by babesia in domestic animals

巴贝斯虫所致家畜贫血的发病机制

• 批准号: 08456156
• 负责人: MAEDE Yoshimitsu
• 金额: $ 5.06万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08456156/
• 关键词: Babesia; Anemia; Oxidative damage; Erythrocytes; Spleen; Platelet; 抗酸化剤; GSH; 血小板凝集; 脾腫; メトヘモグロビン; マクロファージ

The pathogenesis of anemia in dogs with babesiosis was studied.The results were as follows.1. Oxidative damage to erythrocytes was induced by the multiplication of Babesia gibsoni.2. Ultrastructural study have revealed that red pulp of infected dogs contained many platelets in the splenic cords and sinuses. As a result, it appeared to be difficult for many erythrocytes to pass from cords to sinuses.These results suggest that the cause of anemia in dogs with babesiosis was mainly due to the sequestration of erythrocytes in the spleen, in which the destruction of erythrocytes with oxidative damage might be accelerated.

本实验对巴贝虫病犬贫血的发病机制进行了研究，结果如下：1.吉氏巴氏巴氏线虫增殖引起红细胞氧化损伤.超微结构研究表明，感染犬的红髓内脾索和脾窦内含有大量血小板。这些结果表明，巴贝虫病犬贫血的主要原因是红细胞滞留在脾脏中，氧化损伤加速了红细胞的破坏。

项目成果

Musase,T.: "Oxidative Damage and Enhanced Erythrophagocytosis in Canine Erythrocytes Infected with Babesia gibsoni" J.Vet.Med.Sci.58・3. 259-261 (1996)

Musase，T.：“感染吉氏巴贝虫的犬红细胞中的氧化损伤和增强的红细胞吞噬作用”J.Vet.Med.Sci.58・3（1996）。

MURASE,T., UEDA,T., YAMATO,O., TAJIMA,M., MAEDE,Y.: "Oxidative damage and enhanced erythrophagocytosis in canine erythrocytes infected with Babesia gibsoni" Journal of the Veterinary Medical Science. 58 (3). 259-261 (1996)

MURASE,T.、UEDA,T.、YAMATO,O.、TAJIMA,M.、MAEDE,Y.：“感染吉氏巴贝虫的犬红细胞中的氧化损伤和增强的吞噬作用”《兽医医学科学》杂志。

MURASE, T.: "Oxidative damage and enhanced erythrophagocytosis in canine erythrocytes infected with Babesia gibsoni" Journal of the Veterinary Medical Science. 58(3). 259-261 (1996)

MURASE, T.：“感染吉氏巴贝虫的犬红细胞中的氧化损伤和增强的噬红细胞作用”《兽医医学科学杂志》。