淋巴管新生在肿瘤淋巴结转移过程中起关键作用，研究发现肿瘤细胞淋巴结转移之前会诱导淋巴结淋巴管的新生，从而促进肿瘤细胞的淋巴结转移。因此淋巴结的淋巴管新生也许能够作为肿瘤淋巴结转移的早期征象。因此建立一种敏感、无创的影像检测手段显像淋巴结淋巴管新生，就有可能早期发现"高危"淋巴结，减少"非高危"淋巴结活检及手术切除引起的相应并发症。本研究的研究目标着重于：①制备用于监测淋巴管新生双模态19F-MRI/光学分子影像探针;②运用该探针研究淋巴结淋巴管新生与肿瘤细胞淋巴结转移的时相；③应用该探针研究肿瘤与炎症诱导的淋巴结淋巴管新生的影像表现异同，并探讨抗炎或抗肿瘤治疗可否逆转淋巴结淋巴管的新生。此项目的研究结果对于开发监测淋巴管新生的研究工具，建立早期淋巴结淋巴管新生体内分子成像技术，明确肿瘤转移前的"高危"淋巴结具有重要意义。同时为淋巴管新生和肿瘤淋巴结转移的靶向性治疗提供新的研究工具。

Lymphangiogenesis plays a key role in tumor lymph node metastasis. Some studies demonstrated that tumor cell can induce lymphangiogenesis of lymph node before tumor cell metastasis.Thus lymphangiogenesis of lymph node may act as early signs of tumor lymph node metastasis. Therefore,establishing a sensitive, noninvasive imaging probe to exam of lymphangiogenesis of lymph node, there may early find" high-risk" lymph nodes, reduce the corresponding complications due to the " low-risk" lymph node biopsy and resection. The purpose of this study focuses on ① the construction of dual mode 19F-MRI / optical molecular imaging probes; ② using the probe to investigate lymph nodes lymphangiogenesis and lymph node metastasis of tumor cells in vivo; ③using the probe to investigate the difference of tumor induced lymphangiogeneisi and inflammation induced lymphangiogenesis. Meanwhile to explore whether the anti-inflammatory or antineoplastic therapy can reverse lymph node lymphangiogenesis or not. This study is very important for the exploration in vivo imaging probe of lymphangiogenesis , the establishment of in vivo molecular imaging technology for lymph nodes lymphangiogenesis as well as the demonstratation of " high risk" lymph node before tumor metastasis. At the same time, this study will provide a new research tool for studying of lymphangiogenesis and targeted therapy of tumor lymph node metastasis.