Study of functional resection of cirtical epileptogenic foci by cortical cooling

皮质冷却功能性癫痫灶切除研究

• 批准号: 08457357
• 负责人: SUZUKI Ichiro
• 金额: $ 4.8万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457357/
• 关键词: Epilepsy; Cerebral cortex; Cerebral cooling; Radiation

It is necessary to determine the spacial extent of epileptogenic foci and the functional role of epileptogenic zone in the epilepsy surgery for the cortical epilepsy. It is not difficult to define the central area of the epileptogenic zone, but is difficult to demarcate the marginal zone of the epileptogenic zone. It is also difficult to differentiate between the epileptic activity and the activity electrotonically conducted from the remote epileptogenic zone. From this point of view, it is ideal to interfere transiently the cortical activity in order to evaluate the epileptogenic zone and cortical function. Based on these clinical and sientific background, we evaluated the new technique of the cortical cooling for transient and reversible inactivation of epileptogenic foci. In order to analyze the usefulness of this method, we made animal models such as NER (Noda epileptic rat) and EL mouse. However, the volume of the brain of rats or mice was to small to cool the regional brain or whole brain. Furthermore ; stable cooling of the brain of these animals was also difficult. We therefore analysed the effect of the radiation on the epileptogenic activity in these animals. The inhibitory effect of the radiation on the epileptic activity was revealed. We also studied the effect of the regional cooling on the cerebral epileptic activity in man.

在皮质性癫痫的手术治疗中，明确致痫灶的空间范围和致痫带的功能作用是十分必要的。致痫带中心区的界定并不困难，但致痫带边缘区的划界则比较困难。也很难区分癫痫活动和从远处致痫区电紧张传导的活动。从这个角度来看，理想的是瞬时干扰皮质活动，以评估致痫区和皮质功能。基于这些临床和科学背景，我们评价了皮质冷却的新技术，用于致痫灶的短暂和可逆失活。为了分析这种方法的实用性，我们制作了NER（Noda epileptic rat）和EL小鼠等动物模型。然而，大鼠或小鼠的脑体积太小，无法冷却局部脑或整个脑。此外，这些动物的大脑的稳定冷却也很困难。因此，我们分析了辐射对这些动物癫痫活动的影响。辐射对癫痫活动有抑制作用。我们还研究了局部降温对人脑癫痫活动的影响。

项目成果

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