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Investigation into Etiology of Idiopathic Scoliosis

特发性脊柱侧弯病因调查

基本信息

批准号：
08650105
负责人：
AZEGAMI Hideyuki
金额：
$ 1.41万
依托单位：
TOYOHASHI UNIVERSITY OF TECHNOLOGY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

项目摘要

Since the appearance of idiopathic scoliosis is characterized by deformation of the spine, etiological research into mechanical aspects can help to establish the foundations for investigation of physiological causes and development of suitable treatments. The objective of this study was to make clear the mechanical etiology of thoracic idiopathic scoliosis, focusing on the hypothesis of a buckling mechanism generated by an imbalance in the growth speeds between the vertebrae and the surrounding structures as advocated by Shinoda et al.and Dickson et al.A finite element model of the spine together with the thoracic cage was maid to analysis growth deformation in the T4 to T10 vertebrae. The results yielded deformation that reduced thoracic kyphosis similar to what is observed in healthy children in early adolescence. In the process of increasing this deformation, the first to the fourth buckling modes were obtained, corresponding to the first bending mode in the coronal plane, the first rotation mode, the first bending mode in the sagittal plane, and the second bending mode in the coronal plane. The shape of the fourth mode agreed well with the clinical shapes. Considering the effect of posture on controlling the generation of these first bending and rotation modes and the absence of major muscles to correct the second bending mode, we presented a hypothesis that the 2nd bending mode in the coronal plane is one of the most likely etiological candidates in the mechanics of thoracic idiopathic scoliosis. To evaluate the growth rate and the shape of the fourth buckling mode precisely, nonlinear analysis using a more refined finite element model and experiment with a mechanical model were attemped. In the term of the research project, we made the finite element model and done a preliminary experiment. Sufficient results will be obtained in the future work.

由于特发性脊柱侧凸的外观以脊柱变形为特征，因此对力学方面的病因学研究可以帮助建立调查生理原因和开发适当治疗方法的基础。本研究旨在阐明特发性胸椎侧凸的力学病因，重点探讨Shinoda等和Dickson等提出的脊柱与周围结构生长速度不平衡导致屈曲机制的假说，并建立脊柱和胸椎的有限元模型，分析T4 ~ T10椎体的生长变形。结果产生的变形，减少胸椎后凸类似于观察到的健康儿童在青春期早期。在增加该变形的过程中，获得第一至第四屈曲模式，对应于冠状面中的第一弯曲模式、第一旋转模式、矢状面中的第一弯曲模式和冠状面中的第二弯曲模式。第四模态的形态与临床形态吻合较好。考虑到姿势对控制这些第一弯曲和旋转模式的产生的影响以及缺乏主要肌肉来纠正第二弯曲模式，我们提出了一个假设，即冠状面中的第二弯曲模式是胸椎特发性脊柱侧凸力学中最有可能的病因候选者之一。为了准确评估第四屈曲模态的增长率和形状，使用更精细的有限元模型进行非线性分析，并使用力学模型进行实验。在课题研究期间，我们制作了有限元模型，并进行了初步的试验研究。在今后的工作中将取得足够的成果。