PromptFLASH: Real-time In-vivo FLASH dosimetry for ion beams with Prompt Gamma X-ray Spectroscopy

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FLASH radiotherapy demonstrates a striking biological sparing effect of normal tissues while keeping similar anti-tumor efficacy, termed the “FLASH effect”. The measurement of dose at ultra-high-dose-rates or FLASH rates is complex as dosimeters may be susceptible to saturation at ultra-high dose rates. An in-vivo method of verifying the delivered FLASH dose is currently not available. It is vital to guarantee the accuracy of the delivered dose during FLASH. The current proposal focuses on a new method for verifying delivered FLASH dose in-vivo using prompt gamma x-ray spectroscopic (PGXS) analysis of irradiated tissue, which uses Gadolinium-Based Contrast Agents (GBCA) to amplify gamma/X-ray emission. A graphite calorimetry methodology will be used as absolute dose reference.