PromptFLASH: Real-time In-vivo FLASH dosimetry for ion beams with Prompt Gamma X-ray Spectroscopy

PromptFLASH：使用 Prompt Gamma X 射线光谱仪对离子束进行实时体内 FLASH 剂量测定

• 批准号: 528201597
• 负责人: Professor Dr. Oliver Jäkel
• 金额: --
• 依托单位: Abteilung Medizinische Physik in der Strahlentherapie
• 依托单位国家: 德国
• 项目类别: New Instrumentation for Research
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/528201597?language=en
• 关键词: PromptFLASH; Real; time; vivo; FLASH

FLASH radiotherapy demonstrates a striking biological sparing effect of normal tissues while keeping similar anti-tumor efficacy, termed the “FLASH effect”. The measurement of dose at ultra-high-dose-rates or FLASH rates is complex as dosimeters may be susceptible to saturation at ultra-high dose rates. An in-vivo method of verifying the delivered FLASH dose is currently not available. It is vital to guarantee the accuracy of the delivered dose during FLASH. The current proposal focuses on a new method for verifying delivered FLASH dose in-vivo using prompt gamma x-ray spectroscopic (PGXS) analysis of irradiated tissue, which uses Gadolinium-Based Contrast Agents (GBCA) to amplify gamma/X-ray emission. A graphite calorimetry methodology will be used as absolute dose reference.

FLASH放疗表现出对正常组织显着的生物保护作用，同时保持相似的抗肿瘤功效，称为“FLASH效应”。超高剂量率或闪速率下的剂量测量很复杂，因为剂量计在超高剂量率下可能容易饱和。目前尚无验证所传递的 FLASH 剂量的体内方法。确保 FLASH 期间输送剂量的准确性至关重要。目前的提案重点关注一种使用受照射组织的即时伽马 X 射线光谱 (PGXS) 分析来验证体内传递的 FLASH 剂量的新方法，该方法使用钆基造影剂 (GBCA) 来放大伽马/X 射线发射。石墨量热法将用作绝对剂量参考。