HELIOS – Developing a HELium Imaging Oncology Scanner for Range Guided Radiotherapy (RGRT) for Non-Small Cell Lung Carcinoma (NSCLC)
HELIOS â 开发用于非小细胞肺癌 (NSCLC) 范围引导放射治疗 (RGRT) 的氦成像肿瘤扫描仪
基本信息
- 批准号:457509854
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:New Instrumentation for Research
- 财政年份:
- 资助国家:德国
- 起止时间:
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The goal of radiotherapy (RT) for lung cancer is to deliver radiation dose to the tumor while minimizing exposure of sensitive organs at risk (OARs) such as lung, heart and esophagus. Treatment has, therefore, always been a trade-off between tumor control and organ toxicity. However, in the lung many times the tumors are moving due to patient breathing. Changes in patient anatomy due to motion can occur at time scales ranging from seconds (intrafractional) to days or even several weeks (interfractional). The benefit of carbon ion therapy is challenged by both interfractional anatomical changes and intrafractional motion. In the treatment of moving lung tumors, the benefit of particle therapy is significantly reduced due to the impact of tumor motion and range uncertainties increasing the radiation dose to the OARs. We propose to develop an Helium Imaging Oncology Scanner (HELIOS) to facilitate range guided radiotherapy (RGRT) to reduce toxicity in carbon ion therapy of non-small cell lung carcinoma (NSCLC), by in-vivo monitoring of the delivered dose to a moving tumor. The RGRT approach is based on a carbon beam with mixed-in helium ions, resulting in helium ions exiting the patient due to their longer range at same energy per nucleon. The exiting helium ions will allow for in-vivo and real-time monitoring of the carbon Bragg peak within the patient with 2mm accuracy, reducing the amount of healthy tissue that is irradiated. This will reduce patient toxicity and allow for improved tumor control.To develop HELIOS, we apply for funding for detector components and research personnel to implement hardware & software for the use of HELIOS in a clinical research environment. A more experienced postdoctoral researcher will tackle the commissioning and validation of the HELIOS prototype at the Heidelberg Ion Therapy Center (HIT) through construction of an appropriate lung phantom and corresponding measurements. Here, the project can rely on substantial preliminary work investigating helium/carbon mixing. A PhD student will concurrently develop the algorithms necessary for RGRT treatment planning and image processing for HELIOS. This includes Monte Carlo simulation of dose and range radiographs on 4D imaging data as well as uncertainty estimates. The PhD student can rely on the open-source research treatment planning toolkit matRad developed at DKFZ and validated at HIT, which serves as powerful backbone for the software development and further use in research.The final phase of the project will bring together both HELIOS hardware and software to pave the way for upcoming basic and clinical research projects and application scenarios. Focus will lie on correlating further online in-room data, in particular surface images, to the dose planning simulations and range measurements to develop research protocols and clinical decision criteria for RGRT with HELIOS.
肺癌放射治疗 (RT) 的目标是向肿瘤提供放射剂量,同时最大限度地减少对肺、心脏和食道等敏感器官 (OAR) 的暴露。因此,治疗始终是肿瘤控制和器官毒性之间的权衡。然而,在肺部,肿瘤多次由于患者呼吸而移动。由于运动而导致的患者解剖结构的变化可能会在几秒(分次内)到几天甚至几周(分次间)的时间范围内发生。碳离子治疗的益处受到分次间解剖变化和分次内运动的挑战。在治疗移动性肺部肿瘤时,由于肿瘤运动和范围不确定性的影响增加了 OAR 的辐射剂量,粒子治疗的益处显着降低。我们建议开发一种氦成像肿瘤扫描仪(HELIOS),通过体内监测移动肿瘤的输送剂量,促进范围引导放射治疗(RGRT),以减少非小细胞肺癌(NSCLC)碳离子治疗的毒性。 RGRT 方法基于混合有氦离子的碳束,由于每个核子能量相同,氦离子的射程更长,因此氦离子会离开患者。排出的氦离子将允许以 2 毫米的精度对患者体内的碳布拉格峰进行体内实时监测,从而减少被照射的健康组织的数量。这将减少患者毒性并改善肿瘤控制。为了开发 HELIOS,我们为探测器组件和研究人员申请资金,以实施在临床研究环境中使用 HELIOS 的硬件和软件。经验丰富的博士后研究员将通过构建适当的肺模型和相应的测量来处理海德堡离子治疗中心 (HIT) 的 HELIOS 原型的调试和验证。在这里,该项目可以依赖于调查氦/碳混合的大量前期工作。一名博士生将同时开发 RGRT 治疗计划和 HELIOS 图像处理所需的算法。这包括 4D 成像数据的剂量和范围射线照片的蒙特卡罗模拟以及不确定性估计。博士生可以依赖 DKFZ 开发并在哈尔滨工业大学验证的开源研究治疗计划工具包 matRad,它是软件开发和进一步研究使用的强大支柱。该项目的最后阶段将汇集 HELIOS 硬件和软件,为即将到来的基础和临床研究项目和应用场景铺平道路。重点将在于进一步将在线室内数据(特别是表面图像)与剂量计划模拟和范围测量相关联,以制定 HELIOS RGRT 的研究方案和临床决策标准。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Professor Dr. Oliver Jäkel其他文献
Professor Dr. Oliver Jäkel的其他文献
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{{ truncateString('Professor Dr. Oliver Jäkel', 18)}}的其他基金
Energy-painted ion radiography for precision radiotherapy
用于精准放射治疗的能量涂装离子射线照相
- 批准号:
426970603 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Research Grants
Eine neue Bildgebungstechnik für die Strahlentherapie mit Ionenstrahlen: Die Ionenstrahlbasierte Computertomographie
离子束放射治疗的新成像技术:基于离子束的计算机断层扫描
- 批准号:
216242133 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Research Grants
PromptFLASH: Real-time In-vivo FLASH dosimetry for ion beams with Prompt Gamma X-ray Spectroscopy
PromptFLASH:使用 Prompt Gamma X 射线光谱仪对离子束进行实时体内 FLASH 剂量测定
- 批准号:
528201597 - 财政年份:
- 资助金额:
-- - 项目类别:
New Instrumentation for Research
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