Research on circadian variations of biological variables, such as blood pressure, body temperature, etc.in different sleep-wake patterns.

这项研究的目的是调查生物变量的昼夜变化，当睡眠时相改变时。21.3 cm，170.1 cm，63.8 kg)，在控制的身体条件和生活环境下连续研究72h。睡眠时间第1天为00：00~07：00，第2天为零，第3天为12：00~19：00。口腔温度和皮质醇连续3天有明显的昼夜变化。血压、脉率有明显的双相变化。随着睡眠低谷时期的变化，并突然适应新的作息时间。一些血液和尿液变量在相移后表现出联合变化和钝化的幅度。昼夜节律变化对改变的睡眠-觉醒时间表的调整在不同的变量中以不同的速度发生。主观警觉性在长时间的夜间迅速降低，而在换班睡眠后恢复得更慢和更不有效。对相移的反应也取决于个人。我们将进一步分析所考察变量的节律特征，并考虑到包括受试者个性在内的个体间差异，探索变量或症状之间的关系。

This study was aimed to investigate the changes revealed in circadian variations of biological variables, when a sleep phase was shifted.Nine male students (ave. 21.3yo, 170.1cm, 63.8kg) were studied for 72 hours continuously under a controlled physical conditions and living environment. Sleep hours were from 00 : 00 to 07 : 00 on the 1st day, zero on the 2nd day, and from 12 : 00 to 19 : 00 on the 3rd day.Oral temperature and cortisol kept significant circadian variations for 3 days. Blood pressure and pulse rate had the clear biphasic. variation with the low period during sleep, and adjusted abruptly to the new schedule. Some blood and urinary variables showed combined variations with blunted amplitudes after the phase shift. Adjustment of circadian variations to changed sleep-wake schedules occured at different rates in different variables. Subjective vigilance lowered rapidly during prolonged night, and recovered more slowly and less effectively after the shifted sleep. The reactions to the phase shift also depended on persons.We will further analyze rhythmometric characteristics of variables examined, and explore the relations between variables or symptomes, taking into account of interindividual variability including subject's personality.