Research on circadian variations of biological variables, such as blood pressure, body temperature, etc, in different sleep-wake patterns II

为了研究生物变量昼夜节律变化的变化，当睡眠阶段改变时，七名男生(Ave.1999年，在控制的身体条件和生活环境下，对21.1岁、169.5厘米、65.8公斤体重的个体进行了连续72小时的研究。睡眠时间第1天为00：00~07：00，第2天为零，第3天为12：00~19：00，血压、脉率随睡眠低峰期有明显的双相变化，并迅速适应新的睡眠时程。昼夜节律变化对睡眠-觉醒时间表的调整因受试者的不同而不同。口温和皮质醇的昼夜节律变化持续3天，每天延迟2小时。一些血和尿的变量在相移后表现出组合的变化和钝化的幅度，在不同的变量中以不同的速率调整昼夜变化。主观警觉性在长时间的夜间迅速降低，而在换班睡眠后恢复得更慢和更不有效。对相移的反应也因人而异。我们调查了310名大学生的日常生活时间。在节假日，他们醒来的时间比平日晚1~2小时。其中70%的人在工作日吃早餐，49%的人在节假日吃早餐。不吃早餐的人起床时间比吃早餐的人晚约2小时。我们将进一步分析所检测变量的节律特征，并考虑到个体间的差异，探索变量或症状之间的关系，并报告结果。

To investigate the changes revealed in circadian variations of biological variables, when a sleep phase was shifted, seven male students (ave. 21.1yo, 169.5cm, 65.8kg) were studied for 72 hours continuously under a controlled physical conditions and living environment in 1999. Sleep hours were from 00:00 to 07:00 on the 1st day, zero on the 2nd day, and from 12:00 to 19:00 on the 3rd day.Blood pressure and pulse rate had the clear biphasic variation with the low period during sleep, and adjusted abruptly to the new schedule. Adjustment of circadian variations to changed sleep-wake schedules occurred at different rates by subject. Oral temperature and cortisol kept significant circadian variations for 3 days, with the phase delay of 2 hours per day. Some blood and urinary variables showed combined variations with blunted amplitudes after the phase shift, with adjustment of circadian variations at different rates in the different variables. Subjective vigilance lowered rapidly during prolonged night, and recovered more slowly and less effectively after the shifted sleep. The reactions to the phase shift also depended on persons.We surveyed timings of daily life in 310 university students. On holidays they woke up ca. 1〜2 hours later than on weekdays. 70% of them had breakfast on weekdays, and 49% on holidays. Those who did not eat breakfast woke up ca. 2 hours later than those who had breakfast.We will further analyze rhythmometric characteristics of variables examined, and explore the relations between variables or symptomes, taking into account of interindividual variability, and will report the results.