Pathophysiological and Logical Clinical Study in patients with Sarcoidosm Prognoitic factors

我们试图评估结节病患者的长期预后和预后因素。自发性消退和慢性化是肺结节病患者的两个特征性结局，我们确实将胸片上阴影检出后5年的病例判定为慢性病例，但没有明确的参数来帮助我们预测慢性化是否会进展为纤维化。总的来说，根据868例肺结节病患者的经验，6%的无症状患者和12%的有症状患者在检测到异常阴影后10年内表现出恶化。（检测时的年龄、是否存在实质病变、既往皮质类固醇治疗史、是否存在胸外受累），BALF巨噬细胞中激活的维生素D、血管紧张素II受体基因、IL-1受体拮抗剂/IL-β比值可能是结节病较好的预后因素。

We tried to evaluate long-term prognosis and prognostic factors of patients with sarcoidosis. Spontaneous regression and chronicity are two characteristic fates in patients with pulmonary sarcoidosis.We did judge the cases with 5 years after detection of the shadows on chest radiographs as chronic cases, but there are no definite parameters to help us predict if a chronicity will progress into fibrosis. Overall, based on own experiences of 868 patients with pulmonary, Sarwidosis, 6% of the asymptomatic patients and 12% of the symptomatic cares showed deterioration more them 10 years after detection of the abnormal shadows.In addition to several prognostic factors (age at the detection, presence of parenchymal lesions, and prerious history of treatment with corticosteroids, the presence of extrathoracie involvements), activated vitamin D, angiotencin II receptor gene, IL-I receptor antagonist/IL-β ration in BALF macrophoye seemed to be good prognostic factors of sarcoidosis.