Pathophysiological and Logical Clinical Study in patients with Sarcoidosm Prognoitic factors

我们试图评估结节病患者的远期预后和预后因素。自发性消退和慢性化是肺结节病患者的两个特征命运。我们确实将胸片上发现阴影5年后的病例判断为慢性病例，但没有明确的参数来帮助我们预测慢性是否会进展为纤维化。总体而言，根据868例肺部肉芽肿病患者的自身经验，6%的无症状患者和12%的有症状的护理人员在发现异常阴影10年后出现恶化。除了几个预后因素(发现时的年龄、是否有实质性病变、有无激素治疗史)、胸外病变的存在外，大眼支气管肺泡灌洗液中活化的维生素D、血管紧张素II受体基因、IL-I受体拮抗剂/IL-β比率似乎是结节病的良好预后因素。

We tried to evaluate long-term prognosis and prognostic factors of patients with sarcoidosis. Spontaneous regression and chronicity are two characteristic fates in patients with pulmonary sarcoidosis.We did judge the cases with 5 years after detection of the shadows on chest radiographs as chronic cases, but there are no definite parameters to help us predict if a chronicity will progress into fibrosis. Overall, based on own experiences of 868 patients with pulmonary, Sarwidosis, 6% of the asymptomatic patients and 12% of the symptomatic cares showed deterioration more them 10 years after detection of the abnormal shadows.In addition to several prognostic factors (age at the detection, presence of parenchymal lesions, and prerious history of treatment with corticosteroids, the presence of extrathoracie involvements), activated vitamin D, angiotencin II receptor gene, IL-I receptor antagonist/IL-β ration in BALF macrophoye seemed to be good prognostic factors of sarcoidosis.