Pathophysiological and Logical Clinical Study in patients with Sarcoidosm Prognoitic factors

结节病患者的病理生理学和逻辑临床研究 预后因素

• 批准号: 08670661
• 负责人: NAGAI Sonoko
• 金额: $ 1.41万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670661/
• 关键词: Sarcoidosis; Chronicity; Deteriolation; Proguostic factors; BALF manophge; IL-I receptor antagonist; IL-Iβ; activetal V.D; angiotensis II receptor; 慢性化; 難治化; ACE; マクロファーシ; Tリンパ球; 慢性化の指標; 性差; 骨密度; マクロファージ

We tried to evaluate long-term prognosis and prognostic factors of patients with sarcoidosis. Spontaneous regression and chronicity are two characteristic fates in patients with pulmonary sarcoidosis.We did judge the cases with 5 years after detection of the shadows on chest radiographs as chronic cases, but there are no definite parameters to help us predict if a chronicity will progress into fibrosis. Overall, based on own experiences of 868 patients with pulmonary, Sarwidosis, 6% of the asymptomatic patients and 12% of the symptomatic cares showed deterioration more them 10 years after detection of the abnormal shadows.In addition to several prognostic factors (age at the detection, presence of parenchymal lesions, and prerious history of treatment with corticosteroids, the presence of extrathoracie involvements), activated vitamin D, angiotencin II receptor gene, IL-I receptor antagonist/IL-β ration in BALF macrophoye seemed to be good prognostic factors of sarcoidosis.

我们试图评估结节病患者的长期预后和预后因素。自发性消退和慢性化是肺结节病患者的两个特征性结局，我们确实将胸片上阴影检出后5年的病例判定为慢性病例，但没有明确的参数来帮助我们预测慢性化是否会进展为纤维化。总的来说，根据868例肺结节病患者的经验，6%的无症状患者和12%的有症状患者在检测到异常阴影后10年内表现出恶化。（检测时的年龄、是否存在实质病变、既往皮质类固醇治疗史、是否存在胸外受累），BALF巨噬细胞中激活的维生素D、血管紧张素II受体基因、IL-1受体拮抗剂/IL-β比值可能是结节病较好的预后因素。

项目成果

Takeshi Mikuniya: "Quantitative Evaluation of the IL-1β nad IL-1 receptor antagonist obtained from BALF macrophagas in patients with Interstitial Lung Diseases"Sarcoidosis Vasculitis and Diffuse Lung Diseases. 14. 39-45 (1997)

Takeshi Mikuniya：“从间质性肺病患者的 BALF 巨噬细胞中获得的 IL-1β 和 IL-1 受体拮抗剂的定量评估”结节病血管炎和弥漫性肺病 14. 39-45 (1997)。

Michio Sigematsu: "Summer-type Hypersensitivity Pneumonitis,T-cell Receptor V Gene Usage in BALF T-cells from 3 Cases in One Family"Sarcoidosis Vasculitis and Diffuse Lung Diseases. 15. 173-177 (1998)

Michio Sigematsu：“夏季型过敏性肺炎，一个家族 3 例 BALF T 细胞中 T 细胞受体 V 基因的使用”结节病性血管炎和弥漫性肺病。

Sonoko Nagai: "Bronchoclreclar Lavage : Still useful in diagnosing Sarcoiclorin?" Clinics in Chest Medicine. 18・4. 787-797 (1997)

Sonoko Nagai：“Bronchoclerclar Lavage：在诊断肌氯蛋白方面仍然有用吗？”Clinics in Chest Medicine 18・4 (1997)。

Michio Shigematsu: "Summer-type Hyperserisitivity Pneumonitis.T-cell Recepton V Bene Usage in BALF T-cells from 3 Coses in One Family" Sarcoidosm Vasculitis and Diffuse Lung Disecses. 15. 173-177 (1998)

Michio Shigematsu：“夏季型高过敏性肺炎。T 细胞受体 V Bene 在来自 3 个家族的 BALF T 细胞中的使用”结节性血管炎和弥漫性肺疾病。

Kunio Hamada: "Ionized calcium and 1,25-dihydroxy vitamin D concentration in serum of patients with sarcoidosis"Eur.Respir J. 11. 1015-1020 (1998)

Kunio Hamada：“结节病患者血清中的离子钙和 1,25-二羟基维生素 D 浓度”Eur.Respir J. 11. 1015-1020 (1998)