Anti-neural calcium channel antibodies in amyotrophic lateral sclerosis

最近有研究表明，肌萎缩性侧索硬化症（ALS）患者的抗电压门控钙通道（VGCC）抗体可增强Ca2+电流并导致神经元细胞死亡。虽然已知VGCC中超过6种不同的al亚基亚型，但尚未直接显示ALS中哪一种神经元类型的al亚基是抗体的靶标。在本研究中，我们使用类型特异性抗al亚基抗体，试图揭示ALS血清中与哪些抗体结合的al亚型。抗vgcc抗体在25 - 65%的患者中呈阳性。结果表明，VGCC抗体在ALS血清中的抗al亚群具有异质性。由于抗体的类型特异性因患者而异，这些抗体对ALS病理生理的贡献可能因个体患者而异。

It was recently suggested that anti-voltage-gated calcium channel (VGCC) antibody in patients with amyotrophic lateral sclerosis (ALS) could enhance Ca2+ current and cause neuronal cell death. Although more than six distinct subtypes of al subunit of VGCC have been known, it has not been shown directly which neuronal type of al subunit is the target of antibodies in ALS, In this study, using type specific anti-al subunit antibodies, we tried to reveal al subtypes, to which antibodies in ALS serum bind. Anti-VGCC antibodies are positive in 25 to 65% of patients. The heterogeneity of anti-al subumt of VGCC antibodies in ALS serum was shown. Because type-specificity for antibodies vary among patients, contributions of these antibodies to ALS pathophysiology may differ with individual patients.