Anti-neural calcium channel antibodies in amyotrophic lateral sclerosis

肌萎缩侧索硬化症中的抗神经钙通道抗体

• 批准号: 08670736
• 负责人: FURUTAMA Daisuke
• 金额: $ 1.28万
• 依托单位: Osaka Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670736/
• 关键词: amyotrophic lateral aclerosis; motoneuron; calcium channel; autoantibody; cell death; Amyotrophic latenal Sclersis; VSC 4.1; polyglutamine; SBM4

It was recently suggested that anti-voltage-gated calcium channel (VGCC) antibody in patients with amyotrophic lateral sclerosis (ALS) could enhance Ca2+ current and cause neuronal cell death. Although more than six distinct subtypes of al subunit of VGCC have been known, it has not been shown directly which neuronal type of al subunit is the target of antibodies in ALS, In this study, using type specific anti-al subunit antibodies, we tried to reveal al subtypes, to which antibodies in ALS serum bind. Anti-VGCC antibodies are positive in 25 to 65% of patients. The heterogeneity of anti-al subumt of VGCC antibodies in ALS serum was shown. Because type-specificity for antibodies vary among patients, contributions of these antibodies to ALS pathophysiology may differ with individual patients.

最近有人提出，肌萎缩侧索硬化症（ALS）患者的抗电压门控钙通道（VGCC）抗体可以增强Ca2+电流并导致神经元细胞死亡。尽管已知 VGCC 的 a1 亚基有超过六种不同的亚型，但尚未直接表明哪种神经元类型的 a1 亚基是 ALS 抗体的靶标。在本研究中，我们使用类型特异性抗 a1 亚基抗体，试图揭示 ALS 血清中的抗体所结合的 a1 亚型。 25% 至 65% 的患者抗 VGCC 抗体呈阳性。显示了 ALS 血清中 VGCC 抗体抗亚型的异质性。由于抗体的类型特异性因患者而异，因此这些抗体对 ALS 病理生理学的贡献可能因患者个体而异。

项目成果

木村文治,他: "抗カルシウム・チャネル" 『キーワード1997-98神経変性疾患』. 11-12 (1997)

Bunji Kimura 等人：“抗钙通道”“关键词 1997-98 神经退行性疾病”11-12 (1997)。

中嶋秀人,木村文治,他: "Transcriptional activity by the audrogeu reuptp in X-linked spinal and hulhad muscular atropby" J.Neurol Sci. 142. 12-16 (1996)

Hideto Nakajima、Fumiharu Kimura 等人：“X 连锁脊髓和 hulhad 肌萎缩症中 audrogeu reuptp 的转录活性”J.Neurol Sci. 142. 12-16 (1996)

中嶋秀人,木村文治,他: "Effect of anclrogen receptor polyglutancine tract expausion on proliteration of NG 108-15 cell" Neuroscience letlers. 222. 83-86 (1997)

Hideto Nakajima、Bunji Kimura 等人：“抗激素受体聚谷氨酸束扩张对 NG 108-15 细胞增殖的影响”神经科学快报。 222. 83-86 (1997)

Nakajima-H.et al.: "Analysis of transcriptional regulation of the androgen receptor in X-linked spinal and bulbar muscular atrophy." J.Neurological Science. 142. 12-16 (1996)

Nakajima-H.et al.：“X连锁脊髓和延髓肌萎缩症中雄激素受体转录调控的分析”。

Nakajima-H.et al.: "Effects of androgen receptor polyglutamine tract expansion on proliferation of NG 108-15 cells" Neuroscience Letters. 222. 83-86 (1997)

Nakajima-H.et al.：“雄激素受体聚谷氨酰胺束扩张对 NG 108-15 细胞增殖的影响”神经科学快报。