Osteoporosis-evaluation with MR imaging-

骨质疏松症-磁共振成像评估-

• 批准号: 08670993
• 负责人: YOSHIKAWA Hiroyuki
• 金额: $ 1.34万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670993/
• 关键词: osteoporosis; MRI; T2^*; T2^★; 骨粗髪症

Osteoporosis is characterized by demineralization of bone matrix, and T2^* will be prolonged due to diminution of susceptibility. The purpose of this study is to evaluate osteoporosis with MR imagint. MR images of the lumbar spine were obtained with gradient echo sequence. TR was 500 msec, and TEs were 4.5,9.3,14.1 (in phase), 6.9,11.7, and 16.5 msec (out of phase). Group A was consisted with 13 patients administered steroids for collagen disease, and group B was composed with 11 patients without steroids. T2^* was calculated from the decline of signal intensity - TE line. Mean T2^* values of patients with and without steroid therapy were 0.014 and 0.013, respectively, and there was no significant difference between these two groups. Bone matrix could not be evaluated with these methods.

骨质疏松症以骨基质脱矿为特征，T2^*会因易感性降低而延长。本研究的目的是利用磁共振成像评估骨质疏松症。采用梯度回波序列获得腰椎MR图像。TR为500 msec， te分别为4.5、9.3、14.1（同相）、6.9、11.7、16.5 msec（异相）。A组13例使用类固醇治疗胶原蛋白疾病，B组11例不使用类固醇治疗。T2^*由信号强度衰减- TE线计算。接受和未接受类固醇治疗的患者T2^*平均值分别为0.014和0.013，两组间差异无统计学意义。这些方法无法对骨基质进行评价。