An Experimental Study of the Hybrid Bone with Vascularized Periosteum

1. 我们将骨膜与羟基磷灰石陶瓷相结合，制作了带血管的人工骨模型。我们用Northen印迹法评估血管化骨膜具有成骨能力。我们用显微血管造影评价羟基磷灰石陶瓷术后新生血管的形成情况。血管增生与成骨能力无明显关系。利用骨髓细胞制备了一种新型的血管化人工骨模型。我们对其成骨能力进行组织学和生化评价。我们发现该模型具有术后快速成骨的优点。

1. We made a model of the vascularized artificial bone, combined the periosteumn with the hydroxyapatite ceramics. We evaluated that the vascularized perioteum had an osteogenic capacity using Northen blotting.2. We evaluated the postoperative neovascularization of the hydroxyapatite ceramics using microangiogram. It was no relationship between the vascular proliferation and the osteogenic capacity.3. We made a new model of the vascularized artificial bone with bone marrow cells. We evaluated the osteogenic capacity histologically and biochemically. We found this model had an advantage of the rapid osteogenesis postoperatively.