An Experimental Study of the Hybrid Bone with Vascularized Periosteum

带血管骨膜混合骨的实验研究

• 批准号: 08671683
• 负责人: YAJIMA Hiroshi
• 金额: $ 1.54万
• 依托单位: Nara Medical Univ.
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671683/
• 关键词: hydroxyapatite ceramics; vascularized tissue transplantation; periosteum; osteogenesis; bone marrow cells; ハイドロキシアパタイトセラミクス; 人工骨; 異所性骨化

1. We made a model of the vascularized artificial bone, combined the periosteumn with the hydroxyapatite ceramics. We evaluated that the vascularized perioteum had an osteogenic capacity using Northen blotting.2. We evaluated the postoperative neovascularization of the hydroxyapatite ceramics using microangiogram. It was no relationship between the vascular proliferation and the osteogenic capacity.3. We made a new model of the vascularized artificial bone with bone marrow cells. We evaluated the osteogenic capacity histologically and biochemically. We found this model had an advantage of the rapid osteogenesis postoperatively.

1.制作血管化人工骨模型，将骨膜与羟基磷灰石陶瓷复合。结果：1.应用Norten印迹法评价吻合血管的骨膜具有成骨能力。我们通过微血管造影评估羟基磷灰石陶瓷术后新生血管的情况。血管增殖与成骨能力之间无相关性。我们用骨髓细胞制作了一种新的血管化人工骨模型。我们从组织学和生化学的角度对其成骨能力进行评价。我们发现该模型具有术后快速成骨的优势。