The PHASER in focus

PHASER 成为焦点

• 批准号: 528402160
• 负责人: Dr. Sören Lehmkuhl
• 金额: --
• 依托单位: Institut für Mikrostrukturtechnik (IMT)
• 依托单位国家: 德国
• 项目类别: Independent Junior Research Groups
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/528402160?language=en
• 关键词: PHASER; focus

Over the past decades, nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) have consolidated as analytical tools in physical and medical sciences. Their high information content enabled applications from synthetic chemistry to clinical diagnosis. However, albeit such powerful analytical tools, NMR and MRI suffer from intrinsically low sensitivity. The signal can be boosted over 1000-fold by hyperpolarization technologies. However, precision and amount of the extractable information are still limited. The resolution of an NMR spectrum or image also depends on the possible observation time of the nuclear spins. This limit can be overcome by the RASER, a brother of the LASER based on radiowaves. The objective of this proposal is to design an ultra-high precision detector based on both parahydrogen hyperpolarization and the RASER concept. A one-of-a-kind setup that will be called the PHASER (ParaHydrogen Achieves Super Enhanced Resolution). The PHASER can be operated at low magnetic fields, motivating the design of a miniaturized version. The PHASER setup will enable applications in NMR spectroscopy, microscale MRI, and measurements of external parameters such as magnetic fields, temperatures or rotations.

在过去的几十年里，核磁共振(核磁共振)和磁共振成像(MRI)作为物理和医学科学中的分析工具得到了巩固。它们的高信息量使得从合成化学到临床诊断的应用成为可能。然而，尽管核磁共振和核磁共振是如此强大的分析工具，但它们本身的灵敏度却很低。超极化技术可以将信号放大1000倍以上。然而，可提取信息的精确度和信息量仍然有限。核磁共振谱或图像的分辨率还取决于核自旋的可能观测时间。激光可以克服这一限制，激光是基于无线电波的激光的兄弟。该方案的目的是设计一种基于对氢超极化和激光概念的超高精度探测器。这是一种独一无二的装置，将被称为相位器(仲氢实现超级增强分辨率)。该相位器可以在低磁场下工作，从而激发了微型版本的设计。该相位器设置将支持在核磁共振波谱、微型核磁共振和测量外部参数(如磁场、温度或旋转)中的应用。