The PHASER in focus

在过去的几十年里，核磁共振（NMR）和磁共振成像（MRI）已经巩固了作为物理和医学科学分析工具的地位。它们的高信息量使从合成化学到临床诊断的应用成为可能。然而，尽管如此强大的分析工具，核磁共振和核磁共振本质上存在低灵敏度的问题。通过超极化技术，信号可以增强1000倍以上。然而，可提取信息的精度和数量仍然有限。核磁共振光谱或图像的分辨率也取决于核自旋可能的观测时间。这一限制可以被雷射（RASER）所克服，雷射是基于无线电波的雷射的兄弟。本文的目标是设计一种基于准氢超极化和激光概念的超高精度探测器。一个独一无二的设置，将被称为相位器（ParaHydrogen实现超增强分辨率）。相位器可以在低磁场下工作，从而推动了小型化版本的设计。相位器设置将使应用于核磁共振波谱，微尺度核磁共振，以及测量外部参数，如磁场，温度或旋转。

Over the past decades, nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) have consolidated as analytical tools in physical and medical sciences. Their high information content enabled applications from synthetic chemistry to clinical diagnosis. However, albeit such powerful analytical tools, NMR and MRI suffer from intrinsically low sensitivity. The signal can be boosted over 1000-fold by hyperpolarization technologies. However, precision and amount of the extractable information are still limited. The resolution of an NMR spectrum or image also depends on the possible observation time of the nuclear spins. This limit can be overcome by the RASER, a brother of the LASER based on radiowaves. The objective of this proposal is to design an ultra-high precision detector based on both parahydrogen hyperpolarization and the RASER concept. A one-of-a-kind setup that will be called the PHASER (ParaHydrogen Achieves Super Enhanced Resolution). The PHASER can be operated at low magnetic fields, motivating the design of a miniaturized version. The PHASER setup will enable applications in NMR spectroscopy, microscale MRI, and measurements of external parameters such as magnetic fields, temperatures or rotations.