Short-term effect of frozen-stored disk allograft repair on the osteoarthritic sheep temporomandibular joint

冷冻保存的同种异体椎间盘移植修复骨关节炎羊颞下颌关节的短期效果

• 批准号: 08672347
• 负责人: OGI Nobumi
• 金额: $ 0.9万
• 依托单位: AICHI-GAKUIN UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672347/
• 关键词: temporomandibular joint; osteoarthritis; diskectomy; disk graft; sheep

Aim The aim of this study is to evaluate short-term effect of frozen-stored disk allograft following diskectmy on the osteoarthritic sheep temporomandibular joints (TMJ).Materials and Methods Osteoarthritis was induced in bilateral sheep TMJ.Three months later, unilateral diskectomy and frozen-stored disk allograft repair were performed. The donor disk had been obtained from healthy aheep at sacrifice. The disk was deep-frozen and stored at-70 degrees Celsius for a month and thawed at grafting. The contralateral joints were not disturbed, being served as a control at 3 months. At 6 months after the initial procedure, the sheep were sacrificed.Results All grafted disks were perforated and displaced. In the grafted joints, condylar srticular surface was partly denuded and some part of the surface showed fibrous repair. The control joints showed osteoarthritic changes.Conclusion Frozen-stored allogenic disk has a little indication for an interpositional material in an osteoarthritic TMJ.

目的观察关节盘切除后异体冷冻盘移植对骨关节炎绵羊颞下颌关节（osteoarthritic sheep temporomandibular joints，TMJ）的近期疗效。材料与方法建立绵羊双侧TMJ骨关节炎模型，3个月后行单侧关节盘切除及异体冷冻盘移植修复。供体圆盘在处死时从健康的山羊获得。将圆盘深冻并在-70摄氏度下储存一个月，并在嫁接时解冻。3个月时对侧关节不受干扰，作为对照。在首次程序后6个月，羊被处死。结果所有移植的磁盘被穿孔和移位。移植关节髁突表面部分裸露，部分表面有纤维修复。结论冷冻异体骨盘作为骨关节炎性颞下颌关节间置材料具有一定的适应症。