An experimental study of stored-tendon allograft following discectomy in the rabbit temporomandibular joint.

兔颞下颌关节椎间盘切除术后同种异体肌腱保存的实验研究。

• 批准号: 14571927
• 负责人: OGI Nobumi
• 金额: $ 0.64万
• 依托单位: Aichi-Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571927/
• 关键词: TMJ; disc; tendon; interpositional materials; rabbit

The disc has important biomechanical functions for the temporomandibular joint. However, the pathologic disc has to be removed from painful refractory internally deranged or osteoarthritic temporomandibular joint. There are no ideal interpositional materials at present that can protect articular cartilage from degenerative arthritis following discectomy. The aim of this study is to evaluate the protective effect of disc replacement with stored tendon allograft after disc removal in the rabbit temporomandibular joint.Thirty Japanese. white rabbits were divided into 3 surgical groups as follows : In group 1, unilateral discectomy alone was carried out. In group 2, glutaraldehyde(GA)treated allogenic tendon was grafted as an interpositional material after discectomy. In group 3, epoxy(E)treated allogenic tendon was grafted after discectomy. GA or E was used as a cross-linking agent for tendon collagen. The animals were killed at 3rd post-operative month. The TMJs were removed en bloc, histologically processed and stained with hematoxylin and eosin.Disc replacement with E-treated tendon allografts seems to give promising short-term results following discectomy. GA-treated tendon allografts also have protective effects on condylar articular cartilage. However, in most series, the both GA-treated and Etreated tendon allografts were difficult to survive after disc removal in the temporomandibular joint. The risk of tendon-graft shrinkage or resorption was not prevented.

椎间盘对颞下颌关节具有重要的生物力学功能。然而，病理椎间盘必须从疼痛难治性内部紊乱或骨关节炎的颞下颌关节中移除。目前还没有理想的植入材料可以保护关节软骨免受椎间盘切除术后退行性关节炎的侵害。本研究的目的是评估兔颞下颌关节椎间盘摘除术后同种异体储存肌腱置换术的保护作用。三十日本。将大白兔分为3个手术组，分别为：1组单纯行单侧椎间盘切除术。在第二组，用戊二醛（GA）处理过的同种异体肌腱作为椎间盘切除术后的间位材料进行移植。第3组椎间盘切除术后进行环氧树脂(E)处理的同种异体肌腱移植。用GA或E作为肌腱胶原的交联剂。术后第3个月处死动物。整块切除tmj，进行组织学处理，并用苏木精和伊红染色。椎间盘切除术后，用e -处理过的同种异体肌腱进行椎间盘置换术似乎有很好的短期效果。ga处理的同种异体肌腱移植物对髁突关节软骨也有保护作用。然而，在大多数系列中，ga处理和e处理的同种异体肌腱在颞下颌关节椎间盘切除后都难以存活。没有预防肌腱移植物收缩或吸收的风险。