Physiologic and pathologic functions of a CXC chemokine PBSF/SDF-1 and its receptor CXCR4

趋化因子是一类结构相关的小分子，最初被认为具有调节炎症细胞运输的能力。我们分离出一种趋化因子，基质细胞衍生因子/前B细胞生长刺激因子（SDF-1/PBSF）作为刺激B淋巴细胞前体生长的分子，并发现其在发育中的多种生理功能。我们已经证明，SDF-1/PBSF对胚胎生存能力、B淋巴细胞的发育、造血细胞在骨髓中的定植和心脏发生至关重要。此外，我们还发现了SDF-1/PBSF的小鼠七跨膜g蛋白偶联受体CXCR4，该受体也可作为HIV-1毒株的辅助受体。在这里，我们产生了CXCR4缺陷小鼠，发现CXCR4是SDF-1/PBSF的主要生理受体。

Chemokines are a family of small structurally related molecules that were recognized originally for their ability to regulate cell trafficking in inflammation. We isolated a chemokine, stromal cell-derived factor/pre-B-cell growth stimulating factor (SDF-1/PBSF) as a molecule that stimulates the growth of B lymphocyte precursors and have found its multiple physiological functions in development. We have shown that SDF-1/PBSF is essential for embryonic viability, development of B lymphocyte, colonization of bone marrow by hematopoietic cells and cardiogenesis. Moreover, we identified a murine seven-transmembrane G-protein-coupled receptor for SDF-1/PBSF, termed CXCR4, that also functions as a coreceptor for strains of HIV-1. Here we generated CXCR4 deficient mice and found that CXCR4 was a primary physiologic receptor for SDF-1/PBSF.