TREATMENT OF GINGIVAL OVERGROWTH CAUSED BY MEDICATION

Tenidap， （±）-5-氯-2，3-二羟基-3-（羟基-2-噻吩基甲基化）-2氧-1H-吲哚-1-碳酰胺，是一种新型的抗炎症物质剂，通过尼比平医学对银杏过度生长的抑制进行了调查。在银杏节过度生长后，含有TENI （50毫克/毫升）的种植剂每周一次应用于银杏节特别区域的金丝雀和狗和老鼠中的第一摩尔，对此表示赞赏。Tenidap significantly decreased the depth of periodontal pocket （relative pocket） surrounding canines in dogs。Tenidap也有一个短长度的Rete-peg和瘦epithlium的趋势。这一指数是一个普通的高剂量的Tenidap本地应用程序，可以允许在nifedipine中连续管理nifedipine-反应性患者过度增长。The related compounds which possess the similar effects， such as decrease intracellular pH and deplete calcium store and increase intracellular CaイイD1++イエD1 concentration， to human gingival fibroblasts were also investigated。Diclofenac Na也被证明是为了防止银杏节过度生长而被Nifedipine医学所证实的。

The effect of tenidap, (±)-5-chloro-2, 3-dihydro-3-(hydroxy-2-thienylmethylene)-2 oxo-1H-indole-1-carboxamide, a new anti-inflammatory agent, was investigated on the depression of gingival overgrowth caused by nifedipine medication. After establishment of gingival overgrowth, the ointment containing TENI (50 mg/ml) was applied once a week into the gingival crevicular regions of canines and first molars in dogs and rats, respectively. Tenidap significantly decreased the depth of periodontal pocket (relative pocket) surrounding canines in dogs. Tenidap also gave a trend of shorter length of rete-peg and thinner epithlium. This indicates that a concomitant local application of high dose of tenidap may allow the continuous administration of nifedipine in nifedipine-reactive patients to overgrowth. The related compounds which possess the similar effects, such as decrease intracellular pH and deplete calcium store and increase intracellular CaィイD1++ィエD1 concentration, to human gingival fibroblasts were also investigated. Diclofenac Na was also indicated to prevent gingival overgrowth caused by nifedipine medication.