Sexual dysfunction in patients with schizophrenia treated with antipsychotics

抗精神病药物治疗的精神分裂症患者的性功能障碍

• 批准号: 22791103
• 负责人: FUJII Akira
• 金额: $ 2.41万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791103/
• 关键词: 性機能障害; 抗精神病薬; 性ホルモン; endothelial nitric oxide synthase; 統合失調症; 遺伝子多型; ホルモン; 副作用

The present study revealed that the prevalence of sexual dysfunction in schizophrenic patients treated with antipsychotics was 59.3% for males and 58.9% for females. Almost no sexual dysfunction was correlated with prolactin, sex hormone, endotherial nitric oxide synthase (eNOS) polymorphism (T786C, G894T), but some sexual dysfunction was correlated with the dose of antipsychotics. These findings suggest that sexual dysfunction may be due to the nonspecific effect of antipsychotics (e.g. dopaminergic, serotonergic, histaminergic, cholinergic, adrenergic action).

抗精神病药物治疗的精神分裂症患者性功能障碍患病率男性为59.3%，女性为58.9%。性功能障碍与催乳素、性激素、内源性一氧化氮合酶(ENOS)基因多态性(T786C、G894T)几乎无关，但部分性功能障碍与抗精神病药物的剂量有关。这些发现表明，性功能障碍可能是由于抗精神病药物的非特异性作用(如多巴胺能、5-羟色胺能、组胺能、胆碱能、肾上腺素能作用)所致。

项目成果

Comparing the Influence of Dopamine D2 Polymorphisms and Plasma Drug Concentrations on the Clinical Response to Risperidone

比较多巴胺 D2 多态性和血浆药物浓度对利培酮临床反应的影响

• DOI: 10.1097/jcp.0b013e31822c09a7
• 发表时间: 2011
• 期刊: Journal of Clinical Psychopharmacology
• 影响因子: 2.9
• 作者: N. Yasui‐Furukori;S. Tsuchimine;M. Saito;T. Nakagami;Norio Sugawara;A. Fujii;S. Kaneko
• 通讯作者: S. Kaneko

Endothelial nitric oxide synthase多型の男性性機能障害(特に勃起機能障害)に与える影響について

内皮一氧化氮合酶多态性对男性性功能障碍（尤其是勃起功能障碍）的影响

• 发表时间: 2011
• 作者: Kanno S;Saito M;Hayashi A;Uchiyama M;Hiraoka K;Nishio Y;Hisanaga K;Mori E;藤井学
• 通讯作者: 藤井学

抗精神病薬服用中の統合失調症圏患者における性機能障害と性ホルモンとの関係

服用抗精神病药物的精神分裂症患者性功能障碍与性激素的关系

• 发表时间: 2010
• 作者: 藤井学;古郡規雄;佐藤靖;菅原典夫;中神卓;斉藤まなぶ;兼子直
• 通讯作者: 兼子直

Dose-Dependent Effects of Adjunctive Treatment With Aripiprazole on Hyperprolactinemia Induced by Risperidone in Female Patients With Schizophrenia

• DOI: 10.1097/jcp.0b013e3181ee832d
• 发表时间: 2010-10-01
• 期刊: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
• 影响因子: 2.9
• 作者: Yasui-Furukori, Norio;Furukori, Hanako;Kaneko, Sunao
• 通讯作者: Kaneko, Sunao

No association between bone mass and prolactin levels among patients with schizophrenia

精神分裂症患者的骨量和催乳素水平之间没有关联

• 发表时间: 2011
• 期刊: Hum Psychopharmacol.
• 作者: Sugawara N;Yasui-Furukori N;Fujii A;Saito M;Sato Y;Nakagami T;Tsuchimine S;Kaneko S
• 通讯作者: Kaneko S