High Pressure NMR Study on the Control of Organic Chemical Reaction by Pressure.

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(1).Effect of hydrostatic pressure on the rate of internal rotation of cyclophane derivatives has been examined by DNMR method. Quartz pressure-resisting NMR cells were used to realize the high pressure experiments up to 390 MPa (line shape measurements) and 450 MPa (chemical shift measurements). Application of hydrostatic pressure was found to accelerate the rotation of the benzene ring, while pressure-induced high field chemical shifts of bridge methylene protons indicated that there is a considerable shrinkage of the methylene bridge structure upon pressurization.(2).The technique of using a pressure-resisting cell system for high-pressure high-resolution NMR measurements up to 600 MPa has been accomplished. This system demonstrates capability of performing high-pressure experiments on any standard spectrometer including a modern high field (400-750 MHz) NMR machine. Using this high pressure NMR method, high-pressure studies have been promoted in the field of the high-pressure molecular biology, where performance inherent to the pressure-resisting cell displays its ability to the limit. At present, Kobe University is unrivaled as to this level of experiment.