High Pressure NMR Study on the Control of Organic Chemical Reaction by Pressure.

（1）.用DNMR方法研究了静水压力对环蕃衍生物内旋转速率的影响。使用石英耐压NMR池实现了高达390 MPa（线型测量）和450 MPa（化学位移测量）的高压实验。应用静水压力被发现加速旋转的苯环，而压力引起的高场化学位移的桥亚甲基质子表明，有一个相当大的收缩的亚甲基桥结构加压后。（2）完成了耐压池系统在600 MPa以下的高压高分辨核磁共振测量技术。该系统演示了在任何标准光谱仪上进行高压实验的能力，包括现代高场（400-750 MHz）NMR机器。使用这种高压NMR方法，在高压分子生物学领域中促进了高压研究，其中耐压单元固有的性能显示出其极限能力。目前，科比大学在这一实验水平上无人能敌。

(1).Effect of hydrostatic pressure on the rate of internal rotation of cyclophane derivatives has been examined by DNMR method. Quartz pressure-resisting NMR cells were used to realize the high pressure experiments up to 390 MPa (line shape measurements) and 450 MPa (chemical shift measurements). Application of hydrostatic pressure was found to accelerate the rotation of the benzene ring, while pressure-induced high field chemical shifts of bridge methylene protons indicated that there is a considerable shrinkage of the methylene bridge structure upon pressurization.(2).The technique of using a pressure-resisting cell system for high-pressure high-resolution NMR measurements up to 600 MPa has been accomplished. This system demonstrates capability of performing high-pressure experiments on any standard spectrometer including a modern high field (400-750 MHz) NMR machine. Using this high pressure NMR method, high-pressure studies have been promoted in the field of the high-pressure molecular biology, where performance inherent to the pressure-resisting cell displays its ability to the limit. At present, Kobe University is unrivaled as to this level of experiment.