Studies on high-dimensional functions of glycoconjugates toward development of new medicines and biomaterials

复合糖的高维功能研究用于新药和生物材料的开发

• 批准号: 10660107
• 负责人: ISHIDA Hideharu
• 金额: $ 2.05万
• 依托单位: GIFU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10660107/
• 关键词: Autoimmune Disease; Neural injury; Auto antibody; Ganglioside; Guillain-Barre; 糖鎖工学; 微量ガングリオシド; ギラン・バレー症候群; カンピロバクター・ジェジュニ; リポ多糖

Certain species of anti-gangliosides are associated with specific clinical features in various neurologic diseases such as Guillain-Barre syndrome (GBS). In this project, two kinds of glyco-conjugates were synthesized to clarify the mechanism to cause GBS as well as the mechanism to produce autoantibodies to gangliosides. One is the minor ganglioside with the complex structure, GalNAc-GD1a, Lactoganglio-1 and Lactoganglio-2, which are found in nervous system. Another is Lipopolysaccharide (LPS) of Campylobacter jejuni (C.jejuni) which is known to infect the patients of GBS prior to appearance of GBS.All of the target molecules have been synthesized successfully in our hands, and the evaluation of the functions of these molecules are now under investigation.

某些种类的抗神经节苷脂与各种神经系统疾病（如格林-巴利综合征（GBS））的特定临床特征相关。本课题合成了两种糖缀合物，以阐明GBS的发病机制以及产生抗神经节苷脂自身抗体的机制。一种是在神经系统中发现的具有复杂结构的次要神经节苷脂，GalNAc-GD 1a、Lactoganglio-1和Lactoganglio-2。另一个是空肠弯曲菌（Campylobacter jejuni，C.jejuni）的脂多糖（Lipopolysaccharide，LPS），它是GBS患者在GBS出现之前感染的病原菌。

项目成果

Sawada, N., Ito, M., Ishida, H.and Kiso, M.: "The first synthesis of glycan parts of lactoganglio- and neolactoganglio-series gangliosides"Tetrahedron Lett.. 42. 1745-1747 (2001)

Sawada, N.、Ito, M.、Ishida, H. 和 Kiso, M.：“乳神经节-和新乳神经节-系列神经节苷脂的聚糖部分的首次合成”Tetrahedron Lett.. 42. 1745-1747 (2001)

Sawada et al.: "The first synthesis of glycan parts of lactoganglio-and neolacto"Tetrahedron Letters. 42. 1745-1747 (2001)

Sawada 等人：“首次合成乳神经节和新乳糖的聚糖部分”四面体快报。

X.Zhang et al.: "Chemoenzymatic Synthesis of ganglioside GM4 analogs as potemeial immunosuppressive agents"J.Carbohydr.Chem.. 18(2). 225-239 (1999)

X.Zhang等人：“作为潜在免疫抑制剂的神经节苷脂GM4类似物的化学酶法合成”J.CarboHydr.Chem.. 18(2)。

M.Okada et al.: "Antibodies to GDI2 and to GQIB in Guillain-Barre Symdrome and the related disoeder"Neurological Sciences. 165. 126-132 (1999)

M.Okada 等人：“格林-巴利综合征及相关疾病中 GDI2 和 GQIB 的抗体”神经学科学。

N.Sawada et al.: "Ganglioside GDI2 analogues as high-affinity ligands for myelin-associated glycoprotein(MAG)"Carbohydr.Res,. 316. 1-5 (1999)

N.Sawada 等人：“神经节苷脂 GDI2 类似物作为髓磷脂相关糖蛋白 (MAG) 的高亲和力配体”CarboHydr.Res,。