Elucidation of functions of animal lectins by employing synthetic ligands

使用合成配体阐明动物凝集素的功能

• 批准号: 21603007
• 负责人: ISHIDA Hideharu
• 金额: $ 3.08万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21603007/
• 关键词: 糖鎖リガンド; MBP; シグレック; 動物レクチン; シアル酸; ルイスa

Functions of siglec-2 expressed on B cell and mannan-binding protein(MBP) concerned with innate immunity were studied by employing their synthetic ligands as well as inhibitors. A novel, potent inhibitor of siglec-2 was developed based on the structure-activity relationship of a series of sialosides as siglec-2 ligands, and which was found to be significantly effective to protect mice from the infection with influenza virus.

利用合成的配体和抑制剂研究了B细胞上表达的siglec-2和与先天免疫相关的甘露聚糖结合蛋白（MBP）的功能。基于一系列sialosides作为siglec-2配体的构效关系，开发了一种新型的siglec-2抑制剂，并发现其对流感病毒感染小鼠具有显著的保护作用。

项目成果

Design and Synthesis of a Multivalent Heterobifunctional CD22 Ligand as a Potential Immunomodulator

• DOI: 10.1055/s-0030-1260151
• 发表时间: 2011-09-01
• 期刊: SYNTHESIS-STUTTGART
• 影响因子: 2.6
• 作者: Abdu-Allah, Hajjaj H. M.;Watanabe, Kozo;Kiso, Makoto
• 通讯作者: Kiso, Makoto

A First Total Synthesis of a Hybrid-Type Ganglioside Associated with Amyotrophic Lateral Sclerosis-Like Disorder

• DOI: 10.1002/chem.201002184
• 发表时间: 2011-01-01
• 期刊: CHEMISTRY-A EUROPEAN JOURNAL
• 影响因子: 4.3
• 作者: Nakashima, Shinya;Ando, Hiromune;Kiso, Makoto
• 通讯作者: Kiso, Makoto

Synthesis of 6-deoxy-D-altrose used as an authentic sample to identify an unknown monosaccharide isolated from the fruiting body of an edible mushroom

合成 6-脱氧-D-阿卓糖作为真实样品来鉴定从食用菌子实体中分离的未知单糖

• 发表时间: 2011
• 期刊: HETEROCYCLES
• 影响因子: 0.6
• 作者: Yamada;M.;Yoshida;F.;Ando;H.;Ishida;H.;Kiso;M.;Tako;M.
• 通讯作者: M.

脂質ラフトの1分子追跡実験を指向した蛍光ガングリオシドプローブの合成と機能検証2

用于脂筏单分子追踪实验的荧光神经节苷脂探针的合成及功能验证2

• 发表时间: 2011
• 作者: 河村奈緒子;安藤弘宗;池田泰祐;鈴木健一;楠見明弘;石田秀治;木曽真
• 通讯作者: 木曽真

Exploring structure-affinity relationships of CD22-inhibitors

探索 CD22 抑制剂的结构亲和关系

• 发表时间: 2009
• 作者: Abdu-Allah;H. H. M.;T. Tamanaka;C. Takaku;Yu;J.;Lu;Z.;Magesh;S.;T. Adachi;Tsubata;T.;Ishida;H.;and Kiso;M.
• 通讯作者: M.