Studies on the chemical cues involved in larval metamorphosis and settlement in marine invertebrates.
研究海洋无脊椎动物幼虫变态和定居所涉及的化学线索。
基本信息
- 批准号:10660172
- 负责人:
- 金额:$ 1.02万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 2000
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Various chemical signals involved in larval metamorphosis and settlement of macrofouling organisms were examined for serpulid polychaete Hydroides ezoensis. We isolated and indentified a new monoacyl glycerol, 1-(4Z, 7Z, 10Z, 13Z, 16Z, 19Z)-docosahexaenoyl-glycerol as a metamorphosis inducing substance of larvae of H.ezoensis form MeOH extract of adult tube clumps of the same species. This result indicates that this substance attributes the gregarious settlement exhibited by this species. Various related compounds such as free fatty acids or their glycerids were also examined for their abilities to induce larval metamorphosis of H.ezoensis. In FFA's, only unsaturated FFA's induced larval metamorphosis and the metamorphosis-inducing activities depend on the presence and the number of unsaturated bonds of FFA's. Glycerids exhibited higher activities than FFA's.Among artificial metamorphosis inducer, L-3,4-dihydroxyphenylalanine (L-DOPA) and neurotransmitter epinephrine induced larval metamorphosis in H.ezoensis.Enantiomer of L-DOPA, D-DOPA, which is inactive in vertebrates, also induced larval metamorphosis in lower degree. This result indicates the possibility that dopamine-receptor of different type from that of vertebrates may be involved in larval metamorphosis in H.ezoensis.Among several agonists of epinephrine tested, any specific agonists of α_1, α_2, or β type receptor exhibited clear results. This result indicates the possibility that adrenaline-receptor of different type from that of vertebrates may be involved in larval metamorphosis in H.ezoenssis.Excess K^+ and Ca^<2+> ion in seawater also induced larval metamorphosis in dose dependently. Decrease of Ca^<2+> in seawater blocked the induction of larval metamorphosis by L-DOPA, indicating that induction of larval metamorphosis induced by excess Ca^<2+> may locate lower stream of cascades than that of L-DOPA.
研究了多毛纲软体动物Hydroides ezoensis在大型污损生物幼虫变态和定居过程中的各种化学信号。本文报道了一种新的单酰基甘油1-(4 Z,7Z,10 Z,13 Z,16 Z,19 Z)-二十二碳六烯酰甘油的分离鉴定。这一结果表明,这种物质属性的群居定居所表现出的这种物种。各种相关的化合物,如游离脂肪酸或其甘油酯也检查了它们的能力,以诱导幼虫变态的血吸虫。在游离脂肪酸中,只有不饱和的游离脂肪酸才能诱导幼虫变态,而变态诱导活性取决于游离脂肪酸中不饱和键的存在和数量。在人工变态诱导剂中,L-3,4-二羟基苯丙氨酸(L-DOPA)和神经递质肾上腺素能诱导虾夷扇贝幼虫变态,而在脊椎动物中无活性的L-DOPA对映体D-DOPA也能诱导虾夷扇贝幼虫变态,但诱导程度较低。这一结果表明,与脊椎动物不同类型的多巴胺受体可能参与了虾夷扇贝幼虫的变态过程,在所测试的几种肾上腺素激动剂中,α_1、α_2和β型受体的任何一种特异性激动剂都有明确的结果。这一结果表明,与脊椎动物不同类型的肾上腺素受体可能参与了海蜇幼虫的变态过程,海水中过量的K^+和Ca^<2+>离子也能诱导海蜇幼虫的变态,并呈剂量依赖性。海水中Ca^<2+>浓度的降低阻断了L-DOPA对幼虫变态的诱导作用,表明过量Ca^<2+诱导幼虫变态可能位于L-DOPA诱导的级联下游。
项目成果
期刊论文数量(16)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
岡本研: "Induction of larval metamorphosis in serpulid polychaetes by L-DOPA and Catecholamines."Fisheries Science. 61・1. 69-74 (1995)
冈本实验室:“L-DOPA 和儿茶酚胺诱导蛇类多毛类幼虫变态”。渔业科学 61・1(1995 年)。
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N.Watanabe, S.Watanabe, J.Ide, Y.Watanabe, K.Sakata, and K.Okamoto.: "Chemical signals involved in larval metamorphosis in Hydroides ezoensis (Serpulidae ; Polychaeta). II.Isolation and identification of a new monoacyl glycerol from adult tube clumps as a
N.Watanabe、S.Watanabe、J.Ide、Y.Watanabe、K.Sakata 和 K.Okamoto.:“涉及 Hydroides ezoensis(Serpulidae;Polychaeta)幼虫变态的化学信号。II.一种新的分离和鉴定
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K.Okamoto,A.Watanabe,K.Sakata,and N.Watanabe: "Chemical signals involved in larval metamorphosis in Hydroides ezoensis (Serpulidae ; Polychaeta). Part I. Induction of larval metamorphosis by extracts of the adult tube clumps." J.Marine Biotechnology. 6(1)
K.Okamoto、A.Watanabe、K.Sakata 和 N.Watanabe:“Hydrides ezoensis(Serpulidae;Polychaeta)幼虫变态过程中涉及的化学信号。第一部分。通过成虫管丛提取物诱导幼虫变态。”
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渡辺修治: "Chemical signals involved in larval metamorphosis in Hydroides ezoensis (Serpulidae ; Polychaeta). II.Isolation and identification of a new monoacyl glycerol from adult tube clumps as a metamorphosis-inducing substance."Journal of Marine Biotechnol
Shuji Watanabe:“涉及Hydrides ezoensis(Serpulidae;Polychaeta)幼虫变态的化学信号。II.从成虫管丛中分离和鉴定一种新的单酰基甘油作为变态诱导物质。”海洋生物技术杂志
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岡本研・渡辺修治: "カサネカンザシ幼生の変態,着底." 月刊 海洋. 29(4). 257-264 (1997)
冈本实验室,Shuji Watanabe:“Kasane Kanzaki 幼虫的变态和底部着陆。” 月刊 Kaiyo 257-264(1997)。
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OKAMOTO Ken其他文献
OKAMOTO Ken的其他文献
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{{ truncateString('OKAMOTO Ken', 18)}}的其他基金
Systemic and long term analysys of O2- hyperproduction mice
产氧过多小鼠的系统和长期分析
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24590393 - 财政年份:2012
- 资助金额:
$ 1.02万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Phasogenesis study of XOR mutant knock-in mouse.
XOR突变基因敲入小鼠的阶段发生研究。
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20590317 - 财政年份:2008
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$ 1.02万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular basis of structure-based drug design
基于结构的药物设计的分子基础
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18590276 - 财政年份:2006
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$ 1.02万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study of Communication under Noisy Environment.
噪声环境下的通信研究。
- 批准号:
59480346 - 财政年份:1984
- 资助金额:
$ 1.02万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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