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A STUDY ON THE TEMPORAL CORRELATIONS OF THE FUNCTIONAL BRAIN AREAS USING FUNCTIONAL MRI

使用功能 MRI 研究大脑功能区域的时间相关性

基本信息

批准号：
10670039
负责人：
KUWATA Kazuo
金额：
$ 1.73万
依托单位：
GIFU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670039/
关键词：
fMRI SPM Stereopsis MTC MTC-EPI Stuttering FLMT MTC-EPI 視覚情報処理空間認識認知台体視

项目摘要

Using a clinical MRI machine (GE Horizon 1.5 T), we conducted the functional magnetic resonance imaging (fMRI) experiments. Two kinds of methods were employed for the image acquisition, i.e. the whole brain image and the selected plane image. Statistical parametric mapping (SPM) method was mainly employed for the statistical image analysis.Primary motor area and pre-motor area were activated under the finger opposition tasks. Phase shift was observed between two regions, suggesting the time-dependent phase delay (correlation) between two regions.Broca's and frontal association area were activated during the word generation task. On the other hand, no activation was observed around the classical language area for the stuttering subjects. Instead, the activation of the anterior cingulate gyrus in the opposite side was observed. This is quite curious in light of the function of the anterior cingulate.V2, V3, V5, IPS, STS and Broca's area were significantly activated by the stereopsis of the random dot stereogram based on the binocular disparity, indicating that the M-pathway is mainly involved. Frequency labeled multiple task (FLMT) method has been developed in order to analyze the inter-task interference. Broca's area did not interfere with other tasks, but not activated during monocular stereopsis, suggesting that this region is definitely involved in the distance evaluation from the binocular disparity. However, we could not observe any phase shift between the activated areas, suggesting that the stereopsis is processed in the human brain quite rapidly.MTC-EPI method has been successfully applied to the finger opposition task. MTC-EPI was more sensitive to the brain activation compared to ordinary EPI using only the BOLD effect. On the other hand, MTC-EPI is not much sensitive for stereopsis so far. MTC-EPI may be advantageous for the localized activation. However, to conclude this, further investigation would be required.

采用GE Horizon 1.5 T临床核磁共振成像仪进行功能磁共振成像（fMRI）实验。图像采集采用了全脑图像和选定平面图像两种方法。统计图像分析主要采用统计参数映射（SPM）方法。在手指对立任务下，初级运动区和前运动区被激活。在两个区域之间观察到相移，表明两个区域之间存在随时间变化的相位延迟（相关性）。在单词生成任务中，布洛卡区和额叶联合区被激活。另一方面，在口吃的受试者中，古典语言区域没有被激活。相反，观察到另一侧的前扣带回被激活。考虑到前扣带的功能这是很奇怪的。基于双眼视差的随机点立体图立体视觉显著激活了V2、V3、V5、IPS、STS和Broca’s区，表明m通路主要参与其中。为了分析任务间干扰，提出了频率标记多任务（FLMT）方法。布洛卡区不干扰其他任务，但在单眼立体视时没有激活，这表明该区域肯定参与了双眼视差的距离评估。然而，我们没有观察到激活区域之间的相移，这表明立体视觉在人脑中的处理非常迅速。MTC-EPI方法已成功应用于手指对立任务。与仅使用BOLD效应的普通EPI相比，MTC-EPI对大脑激活更敏感。另一方面，目前MTC-EPI对立体视觉的敏感性不高。MTC-EPI可能有利于局部激活。然而，要得出这个结论，还需要进一步的调查。

项目成果

期刊论文数量（31）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

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通讯作者：

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