Direct detection of brain function using magnetic resonance imaging

使用磁共振成像直接检测大脑功能

• 批准号: 07680714
• 负责人: KUWATA Kazuo
• 金额: $ 1.47万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07680714/
• 关键词: MRI; MTC; BOLD effect; task sequence; brain function; fMRI; recognition; will; EPI; 認知; 迷走神経; 脳機能イメージング; 水和

Transient magnetization transfer phenomena was theoretically formulated and analyzed in order for the clinical application of MTC to detect the brain function directly. It was found to be possible to analyze the transient MTC effect by assuming the pseudo-steady state in MTC explicitly incorporating the T_1 discrimination effect. Acquisition parameters in MTC imaging sequence was optimized using the simulation of the theoretical formalism. A fortran program was coded to extract the relevant relaxation parameters from the off-resonance dispersion curve using the non-linear curve fitting procedure. Currently we are applying this technique to detect the brain activation during various tasks in EPI image sequence where MTC contribution, which reflects neuronal excitation directly, would be superimposed on the BOLD effect.On the other hand, we designed a new mutli-dimensional task sequence by which we can separate multiple tasks and their correlation simultaneously by a multiple frequency task labeling technique. We are currently applying this technique to detect various brain functions, such as numerical calculation, stereopsis, sentence recognition etc. We have detected an activation related to 'willingness' up to now.

为了使磁共振成像技术在临床上直接检测脑功能，对瞬态磁化转移现象进行了理论推导和分析。通过假设MTC中的准稳态明确地包含T_1分辨效应，可以分析瞬态MTC效应。利用理论公式对MTC成像序列中的采集参数进行了优化。利用非线性曲线拟合方法，编制了相应的Fortran程序，从非共振色散曲线中提取了相关的弛豫参数。目前，我们正在将该技术应用于EPI图像序列中不同任务的脑激活检测，其中MTC贡献直接反映了神经元的兴奋，将其叠加在BOLD效应上;另一方面，我们设计了一种新的多维任务序列，通过多频任务标记技术可以同时分离多个任务及其相关性。我们目前正在应用这项技术来检测各种大脑功能，如数字计算，立体视觉，句子识别等，我们已经检测到激活有关的“意愿”到现在。

项目成果

T.R.Kim, Y.Goto, N.Hirota, K.Kuwata and C.A.Batt: "High level expression of bovine beta-Lactoglobulin in Pichia pastoris and characterization of its physical properties" Prot.Eng. (in press).

T.R.Kim、Y.Goto、N.Hirota、K.Kuwata 和 C.A.Batt：“牛 β-乳球蛋白在毕赤酵母中的高水平表达及其物理特性的表征”Prot.Eng。

Kazuo Kuwata: "Clinical applicability of functional magnetic resonance imaging and activation study with single photon emission computerized tomography for functional mapping" Neurol.Res.in press. 20.

Kazuo Kuwata：“功能磁共振成像的临床适用性和使用单光子发射计算机断层扫描进行功能映射的激活研究”Neurol.Res.in 出版社。

K.Kuwata, S.Sato, S.Era, M.Sogami, K.Kida, T.Iwama, K.Kato, T.Matsunaga and H.Watari: "Cross-relaxation times of normal and biochemically induced osteoarthritic rabbit knee cartilages" Jpn.J.of Physiol.47. 291-297 (1997)

K.Kuwata、S.Sato、S.Era、M.Sogami、K.Kida、T.Iwama、K.Kato、T.Matsunaga 和 H.Watari：“正常和生化诱导的骨关节炎兔膝关节软骨的交叉松弛时间

A.Hayakawa, K.Kuwata, S.Era, M.Sogami, H.Shimonaka, M.Yamamoto, S.Dohi and H.Hirose: "Alteration of redox state of human serum albumin in patients under anesthesia and invasive surgery" J.Chromatogr.B 698. 27-33 (1997)

A.Hayakawa、K.Kuwata、S.Era、M.Sogami、H.Shimonaka、M.Yamamoto、S.Dohi 和 H.Hirose：“麻醉和侵入性手术患者中人血清白蛋白氧化还原状态的改变”J

Kazuo Kuwata: "Alteration of redox state of human serum albumin in patients under anesthesia and invasive surgery" J.Chromatogr.B. 698. 27-33 (1997)

Kazuo Kuwata：“麻醉和侵入性手术患者中人血清白蛋白氧化还原状态的改变”J.Chromatogr.B。