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CLINICOPATHOLOGIC STUDIES FOR HISTOLOGICAL CLASSIFICATION AND PROGNOSIS OF RHABDOMYOSARCOMA

横纹肌肉瘤组织学分类和预后的临床病理学研究

基本信息

批准号：
10670187
负责人：
HASEGAWA Tadashi
金额：
$ 1.15万
依托单位：
NATIONAL CANCER CENTER
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

1) We reviewed 6 cases of rhabdomyosarcoma as a rare second primary malignancy in children with bilateral retinoblastoma after irradiation treatment. We have concluded that knowledge of the occurrence of rhabdomyosarcoma and appropriate immunohistochemical study are helpful for avoiding a misdiagnosis of recurrent retinoblastoma or Ewing's sarcoma when encountering these patients who developed second small round cell neoplasms.2) We studied immunoreactivity for E-cadherin, the major cadherin of epithelial cells, in 77 cases of a variety of bone and soft tissue sarcomas. We found that E-cadherin was expressed in certain kinds of soft tissue sarcomas, especially those with epithelioid features, suggesting that E-cadherin plays a role in the constitution of their architecture.3) We conducted clinicopathologic study for 24 cases of extrathoracic solitary fibrous tumor that should be differentiated from spindle cell rhabdomyosarcoma, and found their histological variability and potentially aggressive behavior.4) We investigated the prognostic relevance of a histological grading system based on the assessment of proliferative activity in 95 cases of adult soft-tissue sarcomas including 3 rhabdomyosarcomas of the extremities, trunk, head, and neck. An objective histological grading system using ki-67 (MIB-1) was concluded to be more accurate in accessing ability to metastasize, which was strongly correlate with overall survival.

1)回顾6例儿童视网膜母细胞瘤放射治疗后罕见的第二原发癌横纹肌肉瘤的临床资料。我们的结论是，了解横纹肌肉瘤的发生和适当的免疫组织化学研究有助于避免在遇到发生第二个小圆细胞肿瘤的患者时误诊复发的视网膜母细胞瘤或尤文氏肉瘤。2)我们研究了77例各种骨和软组织肉瘤中上皮细胞的主要钙粘附素E-钙粘附素的免疫反应。我们发现E-钙粘蛋白在某些类型的软组织肉瘤中有表达，特别是那些具有上皮样特征的软组织肉瘤，这表明E-钙粘蛋白在其结构的构成中起到了一定的作用。3)我们对24例应与梭形细胞横纹肌肉瘤相鉴别的胸外孤立性纤维肉瘤进行了临床病理研究，发现它们的组织学变异性和潜在的侵袭性。4)我们在95例成人软组织肉瘤的增殖活性评估的基础上，探讨了组织学分级系统的预后相关性。使用Ki-67(MIB-1)的客观组织学分级系统被认为在评估转移能力方面更准确，而转移能力与总体生存密切相关。