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Metabolomic profiling of retinoblastoma (MPR)

视网膜母细胞瘤的代谢组学分析 (MPR)

基本信息

批准号：
10046917
负责人：
Julia Heck
金额：
$ 14.85万
依托单位：
UNIVERSITY OF NORTH TEXAS
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10046917
关键词：
Address Affect Aldehydes Amines Biochemical Process Biological Biological Markers Birth Certificates Blood California Case-Control Studies Child Data Data Analyses Databases Development Diet Dietary Factors Discriminant Analysis Disease Environment Environmental Exposure Environmental Policy Environmental Pollutants Environmental Risk Factor Epidemiology Etiology Exposure to Flame Retardants Food Food Additives Funding Genetic Diseases Goals Grant Health behavior Human Infant Laboratories Lasso Least-Squares Analysis Libraries Life Logistic Regressions Malignant Childhood Neoplasm Malignant Neoplasms Maternal Exposure Measures Metabolic Metabolic Pathway Metabolism Methods Molecular Weight Neonatal Newborn Infant Oligonucleotides Pathway interactions Pediatric Retinoblastoma Peptides Perinatal Exposure Phenotype Physiological Poly-fluoroalkyl substances Polychlorinated Biphenyls Population Population Study Research Resolution Resources Retinoblastoma Risk Risk Factors Sampling Smoking Source Specimen Spottings Statistical Methods Steroids Systems Analysis Targeted Toxins Testing Tobacco Tobacco use Toxin Work Xenobiotics base biological systems bisphenol A cancer prevention case control environmental agent environmental chemical experience innovation interest maternal tobacco use metabolic profile metabolome metabolomics neoplasm registry novel novel strategies offspring organochlorine pesticide phthalates population based prenatal exposure programs rare cancer response screening program stem sugar tool tumor

项目摘要

Project Abstract The Smoking and Embryonal Tumor (SETs) study is a population-based study of retinoblastoma among California children. California has unique resources: 1) a large population allowing for sufficient cases of disease to study rare cancers; 2) stored neonatal blood spots that the state makes available for research; and 3) a Cancer Registry operating since 1988. We have almost a decade of experience studying the epidemiology of retinoblastoma in California and worldwide and studying environmental and dietary exposures. Using funding from California’s Tobacco-Related Disease Research Program, we previously conducted broad- scale metabolomics of biosamples to examine biomarkers of tobacco use in 498 cases and 895 controls. We propose to employ these data in a new and innovative manner combining our expertise in retinoblastoma epidemiology with the resources in Dr. Jones’ laboratory to identify metabolomics exposure markers and potential disease biomarkers for pediatric retinoblastoma. Metabolomics data analyses will be conducted in a targeted as well as untargeted manner to identify and quantify a number of prenatal exposures and their metabolites in neonatal blood spots. This novel approach will be used to identify exposure and disease ‘signatures’ from metabolites in human metabolic pathways and environmental exposures. This will help us test existing and generate new hypotheses about maternal exposures (e.g. diet, environmental exposures) and metabolic states that affect cancer development in the offspring. We expect this application to encourage environmental policies and provide strategies for population-based prevention of cancer.

项目摘要吸烟与胚胎肿瘤(SETS)研究是一项基于人群的视网膜母细胞瘤研究在加州的孩子中。加州拥有独特的资源：1)人口众多，有足够的病例用于研究罕见癌症的疾病；2)国家为研究提供的储存的新生儿血斑；以及3)自1988年开始运作的癌症登记处。我们有近十年的研究经验加州和世界各地视网膜母细胞瘤的流行病学，并研究环境和饮食暴露。利用加州烟草相关疾病研究项目的资金，我们之前进行了广泛的- 生物样本规模代谢组学研究498例和895名对照的烟草使用生物标志物。我们建议以一种新的创新方式应用这些数据，结合我们在视网膜母细胞瘤方面的专业知识流行病学与琼斯博士实验室的资源，以确定代谢组学暴露标记和儿童视网膜母细胞瘤的潜在疾病生物标志物。代谢组学数据分析将在一个以有针对性和无针对性的方式确定和量化一些产前暴露及其影响新生儿血斑中的代谢物。这种新的方法将被用来识别暴露和疾病人类新陈代谢途径和环境暴露中的代谢物的“特征”。这将有助于我们测试现有并产生关于母亲暴露(例如饮食、环境暴露)的新假设以及影响后代癌症发展的代谢状态。我们希望这项申请能鼓励环境政策，并为以人口为基础的癌症预防提供战略。