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The effects of exercises and stresses on the growth of malignant cells and non-specific immune activity

运动和压力对恶性细胞生长和非特异性免疫活性的影响

基本信息

批准号：
10670327
负责人：
MACHIDA Kazuhiko
金额：
$ 2.43万
依托单位：
Waseda University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

We have been tried to clarify the relation between life style and biophylaxis function by many animal experiments, the survey through health administration in elderly people yet. As these results, lesser stress and adequate free running play big role to the improvement of the their biophylaxis which was gained by non-specific immune activity. We tried following three animal experiments to evaluate the influence on the cancer of their life style (stress, physical fitness and nutrition) by the measure of the tumor's weight and some tests for the biophylaxis. We used physical stress (electric stimulation) and psychological stress as stress load methods, voluntary exercise by running wheel and compulsory exercise by tread mill as exercise methods, and selenium and spirulina as the supplements of anti-oxidants.The weight of malignant cells administered from the back skin of rats loaded stresses by two methods increased significantly in comparison with control rats. But surprisingly. those of rats which was given stresses up to the administration of malignant cells and was stopped stress load after it decreased significantly. These results was in accord with the results of neutrophilis function, NK actitivity and mitogenic response of lymphocytes. The weight of malignant cells in voluntary exercise group decreased and NK activity increased significantly in comparison with control group, but those of tread mill group did not change. The weight of malignant cells Se group and Spirulina group decreased both in comparison with control group. Though their biophylaxis function were not recognized big change such as the stress and the exercise experiments, Spirulina with malignant cells group suggested the possibility of the induction of some subsets of lymphocytes

通过动物实验和老年人健康管理调查，试图阐明生活方式与生物防护功能的关系。由此可见，较小的应激和充分的自由活动对提高其非特异性免疫功能所获得的生物防御能力起着重要作用。我们尝试了三个动物实验，通过测量肿瘤重量和生物防护试验来评估生活方式（压力、体能和营养）对癌症的影响。以物理应激（电刺激）和心理应激为应激负荷方法，以跑轮自主运动和踏车强制运动为运动方法，以硒和螺旋藻为抗氧化剂补充，两种方法负荷的大鼠背部皮肤接种恶性肿瘤细胞的重量均较对照组显著增加。但令人惊讶的是。给予应激直至给予恶性肿瘤细胞后停止应激负荷的大鼠，其抗肿瘤活性显著降低。这些结果与淋巴细胞增殖功能、NK活性和促有丝分裂反应的结果雅阁。与对照组相比，随意运动组肿瘤细胞重量明显减轻，NK细胞活性明显升高，而跑步组肿瘤细胞重量无明显变化。与对照组相比，硒组和螺旋藻组的癌细胞重量均降低。虽然在应激和运动实验中，螺旋藻的生物防护功能没有明显的变化，但恶性细胞组提示有诱导某些淋巴细胞亚群的可能性