The role of verotoxin receptors (Gb3) in the infection of O-157

维罗毒素受体 (Gb3) 在 O-157 感染中的作用

• 批准号: 10670406
• 负责人: KITA Toshiro
• 金额: $ 1.98万
• 依托单位: University of Occupational and Environmental Health
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670406/
• 关键词: O157; Gb3; Verotoxin; Human; Rabbit; HUS; LPS induction; Gb3の局在; 免疫組織学; 種属; LPS感差

Verotoxin producing Escherichia coli O157 was identified as a causative agent of hemolytic uremic syndrome (HUS). These syndrome was reported to be caused by vascular endothelial cell damage by the binding of verotoxin to its receptor glycolipid globotriaosylceramide (Gb3). It is well discussed about the possibility that the Gb3 distributions or levels are various different due to the factor of age and sex in human. So in this study, we histologically examined the expression of the Gb3 antigen on human brain and kidney of various age and both sexes in order to clarify whether the localizations of Gb3 receptor related to the development of vascular endothelial damage. Results : Although there were many individual differences about the distributions or levels of Gb3, there were no significant differences in the distributions of Gb3 owing to the sex, but there were strong histological reactions of Gb3 in infant group compare to the adult group.

大肠埃希菌O157是一种能引起溶血性尿毒综合征（HUS）的大肠杆菌。据报道，这些综合征是由维罗毒素与其受体糖脂神经酰胺（Gb3）结合引起的血管内皮细胞损伤引起的。对Gb_3在人体内的分布或水平因年龄和性别因素而有不同的可能性进行了充分的讨论。因此，本研究从组织学角度观察了不同年龄和性别的人脑和肾脏中Gb3抗原的表达，以阐明Gb3受体的定位是否与血管内皮损伤的发生有关。结果如下：虽然Gb3的分布或水平存在许多个体差异，但Gb3的分布没有因性别而存在显著差异，但与成人组相比，婴儿组中Gb3的组织学反应较强。