Analysis of biologically active substances in volved in growth regulation of leukemia cells
白血病细胞生长调节相关生物活性物质分析
基本信息
- 批准号:10670715
- 负责人:
- 金额:$ 1.98万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 1999
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We evaluated effects of a variety of biologically active substances on growth regulation of leukemia cells. We found that proliferation of leukemic cells with Philadelphia chromosome and 11q23 translocation is stimulated by an addition of granulocyte colony-stimulating factor (G-CSF). Moreover, their proliferation was partially inhibited by exogenously added anti-G-CSF monoclonal antibody, suggesting that the GCSF/G-CSF receptor interaction is implicated in the growth regulation of these leukemia cells in a autocrine mechanism. We also showed that a specific inhibitor of tyrosine kinase having JAK-2 activity (AG490) was capable of inducing induction of B-precursor leukemia cells without effect on normal hematopoietic stem cells, suggesting that use of this drug might be useful for ex vivo purging of these leukemic cells for autologous stem cell transplantation. We also showed that erythropoietin and leptin have a moderate stimulatory activity on proliferation of B-precursor leukemia cells, whereas transforming growth factor β has a marked inhibitory activity. These results suggest that these biologically active substances are closely involved in determining destiny of leukemia cells and may be applicable for the treatment of leukemia.
我们评估了多种生物活性物质对白血病细胞生长调节的影响。我们发现,具有费城染色体和11 q23易位的白血病细胞的增殖被添加粒细胞集落刺激因子(G-CSF)刺激。此外,它们的增殖被外源性加入的抗G-CSF单克隆抗体部分抑制,这表明GCSF/G-CSF受体相互作用以自分泌机制参与这些白血病细胞的生长调节。我们还表明,具有JAK-2活性的酪氨酸激酶的特异性抑制剂(AG 490)能够诱导诱导B-前体白血病细胞,而对正常造血干细胞没有影响,这表明使用这种药物可能是有用的,这些白血病细胞的自体干细胞移植的离体净化。促红细胞生成素和瘦素对B前体白血病细胞的增殖有一定的促进作用,而转化生长因子β则有明显的抑制作用。这些结果表明,这些生物活性物质密切参与决定白血病细胞的命运,并可能适用于治疗白血病。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Sugita K, Mori T, Yokota S, Kuroki Ma, O-Koyama T, Inukai T, Iijima K, Goi K, Tezuka T, Kojika S, Shiraishi K, Nakamura M, Miyamoto N, Karakida N, Kagami K, Nakazawa S.: "The KOR-SA3544 antigen predominantly expressed on surface of Philadelphia chromosome
杉田 K、森 T、横田 S、黑木真、O-Koyama T、犬养 T、饭岛 K、Goi K、手冢 T、小鹿 S、白石 K、中村 M、宫本 N、Karakida N、加贺美 K、中泽 S。
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Sugita K, Mon T,et.al.: "The KOR-SA3544 antigen predominantly expressed on surface of Phiadelphia chromosome-positve acute lymphoblastic cells is nonspecific cross-reacting antigen-50/90 (CD66c) and invariably expressed incytoplasm of human leukemia cells
Sugita K、Mon T 等人:“主要在费城染色体阳性急性淋巴细胞表面表达的 KOR-SA3544 抗原是非特异性交叉反应抗原 50/90 (CD66c),并且总是在人类白血病细胞的细胞质中表达
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- 影响因子:0
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M Nakamura, K Sugita,et .al: "p16MTS1/INK4A gene is frepuently inactivated by hypermethylation in childhood acute lymphoblastic lekemia with 11q23 translocation"Leukemia. 13. 884-890 (1999)
M Nakamura、K Sugita 等人:“在伴有 11q23 易位的儿童急性淋巴细胞白血病中,p16MTS1/INK4A 基因经常因高甲基化而失活”。
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- 影响因子:0
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M Nakamura, K Sugita, et al.: "p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation."Leukemia. 13. 884-890 (1999)
M Nakamura、K Sugita 等人:“在伴有 11q23 易位的儿童急性淋巴细胞白血病中,p16/MTS1/INK4A 基因经常因高甲基化而失活。”白血病。
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- 影响因子:0
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Tezuka T, Sugita K,et al.: "Transient increase in CD45PO expression on T lymphocytes in infected newboms."Pediatr.Res.. 43. 283-290 (1998)
Tezuka T、Sugita K 等人:“受感染新生儿 T 淋巴细胞上 CD45PO 表达瞬时增加。”Pediatr.Res.. 43. 283-290 (1998)
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{{ truncateString('SUGITA Kanji', 18)}}的其他基金
CD44-targetted therapy for CD44-high expressing tumors by ultra-low-molecular-weight hyaluronan
超低分子量透明质酸针对 CD44 高表达肿瘤的 CD44 靶向治疗
- 批准号:
25461585 - 财政年份:2013
- 资助金额:
$ 1.98万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of the FLT3/FLT3 ligand system in ALL with 11q23 translocations
11q23 易位 ALL 中的 FLT3/FLT3 配体系统分析
- 批准号:
18591187 - 财政年份:2006
- 资助金额:
$ 1.98万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
anti-leukemic activity of FLT3 inhibitor on childhood acute lymphoblastic leukemia with 11q23 translocation
FLT3抑制剂对11q23易位儿童急性淋巴细胞白血病的抗白血病活性
- 批准号:
16591018 - 财政年份:2004
- 资助金额:
$ 1.98万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of tumor supressor genes p16 and Rb in childhood acute lymphoblastic leukemia
儿童急性淋巴细胞白血病抑癌基因p16和Rb分析
- 批准号:
14570734 - 财政年份:2002
- 资助金额:
$ 1.98万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of immunological reconstitution after allogeneic bone marrow transplantation
异体骨髓移植后免疫重建分析
- 批准号:
06670778 - 财政年份:1994
- 资助金额:
$ 1.98万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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