Early diagnosis and treatment of diseases in central nervous system caused by auto-antibodies against glutamate receptors

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(1) The autoantibodies against whole GluR ε2 moleculesThe autoantibodies were studied in the sera of 41 epileptic patients (chronic progressive epileptia partialis continua of childhood, 8 ; West syndrome, 15 ; Lennox syndrome, 9 ; Localization-related epilepsy, 9) and six controls. Seven of eight patients with chronic progressive epileptia partialis continua of childhood had autoantibodies (IgG and/or IgM) against GluR ε 2, but IgA-type autoantibodies were not detected. The patient without the autoantibodies was studied at the late stage after the disappearance of epileptia partialis continua. The patient whose serum showed absence of anti-GluR3 autoantibodies in another institute, had autoantibodies against GluR ε 2 in this study. The autoantibodies were not detected in the sera of patients with West syndrome, Lennox-Gastaut syndrome, or localization-related epilepsy, and in those of controls.(2) Epitope analysesEpitope analyses showed the autoantibodies were against c-terminal of GluR ε 2 in seven patients, and that additional autoantibodies against n-terminal were shown in a patients transiently. The epitope on c-terminal was near the trans-membrane region.