Molecular Analysis of Brain System Controls under the Pure Genetic Background

我们建立了C57 BL/6小鼠品系表达Cre或诱导型CrePR重组酶基因的海马，纹状体或小脑特异性启动子的控制下。利用脑区选择性基因操作系统，我们分析了控制学习和记忆的脑系统。我们发现纹状体在弱非条件刺激下对恐惧记忆的形成起着重要作用。此外，我们发现，在平行的纤维浦肯野细胞突触的LTD诱导的便利化增强了视动反应的适应，表明在特定的网站的电机控制电路的突触可塑性决定了电机学习的功效。

We established C57BL/6 mouse lines expressing Cre or inducible CrePR recombinase genes under the control of hippocampus-, striatum- or cerebellum-specific promoters. By the use of the brain-region selective gene manipulation system, we have analyzed brain systems that control learning and memory. We found that the striatum is essential for the formation of fear memory under weak unconditioned stimulus. Furthermore, we showed that the facilitation of LTD induction at parallel fiber-Purkinje cell synapses enhances the optokinetic response adaptation, indicating that the synaptic plasticity at the specific site of a motor control circuit determines the efficacy of a motor learning.