Molecular Analysis of Brain System Controls under the Pure Genetic Background

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We established C57BL/6 mouse lines expressing Cre or inducible CrePR recombinase genes under the control of hippocampus-, striatum- or cerebellum-specific promoters. By the use of the brain-region selective gene manipulation system, we have analyzed brain systems that control learning and memory. We found that the striatum is essential for the formation of fear memory under weak unconditioned stimulus. Furthermore, we showed that the facilitation of LTD induction at parallel fiber-Purkinje cell synapses enhances the optokinetic response adaptation, indicating that the synaptic plasticity at the specific site of a motor control circuit determines the efficacy of a motor learning.