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Varicella-zoster virus(VZV) specific secretory IgA antibody in saliva after vaccination

接种疫苗后唾液中出现水痘带状疱疹病毒（VZV）特异性分泌型 IgA 抗体

基本信息

批准号：
10670769
负责人：
TERADA Kihei
金额：
$ 1.28万
依托单位：
Kawasaki Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670769/
关键词：
secretory IgA antibody varicella vaccine chickenpox 不活化水痘ワクチン鼻腔内噴霧

项目摘要

Breakthrough after varicella vaccination occurs in approximately 2.6%- 18.6% of immunocompetent children, but the reason has not clearly been demonstrated. As a first defense, specific secretory IgA antibody on the mucosa plays an important role in preventing invasion of microorganisms. To analyze induction of varicella-zoster virus (VZV) specific secretory IgA after natural infection and vaccination and its booster mechanisms, we examined 143 salivary samples using ELISA. The VZV-secretory IgA values were significantly higher in the matched children after natural chickenpox than in those after vaccination, although the total secretory IgA did not differ between them. Two (7%) of the vaccinees lacked the sIgA antibody. In the elderly and in immunocompromised children, the VZV-secretory IgA values were no lower than those in healthy children, and they did not lack VZV-secretory IgA. The doctors and nurses taking care of patients with chickenpox had higher values than the other groups as did individuals who had had herpes zoster recently. VZV-secretory IgA was thought to be stimulated by exogenous and reactivated endogenous VZV to neutralize VZV with weak activity. These results suggest that low or no induction of VZV-secretory IgA antibody after vaccination may be one of the possible explanations for breakthrough after it.

大约2.6%- 18.6%的免疫能力儿童在接种水痘疫苗后出现突破，但原因尚未得到明确证实。粘膜上特异性分泌IgA抗体作为第一道防线，在防止微生物入侵方面起着重要作用。为了分析水痘-带状疱疹病毒（VZV）自然感染和疫苗接种后特异性分泌IgA的诱导作用及其增强机制，我们采用ELISA法检测了143份唾液样本。自然水痘后配型儿童的vzv分泌IgA值显著高于接种水痘后配型儿童，但总分泌IgA值无显著差异。两名（7%）疫苗接种者缺乏sIgA抗体。在老年人和免疫功能低下儿童中，vzv -分泌IgA值不低于健康儿童，且不缺乏vzv -分泌IgA。照顾水痘患者的医生和护士比其他组有更高的值，最近患过带状疱疹的人也是如此。分泌VZV的IgA被认为是受到外源性VZV和再激活的内源性VZV的刺激，以中和活性较弱的VZV。这些结果提示，疫苗接种后vzv分泌的IgA抗体低诱导或不诱导可能是其突破后的可能解释之一。