Research on receptor of varicella-zoster virus

水痘带状疱疹病毒受体的研究

• 批准号: 15591147
• 负责人: TERADA Kihei
• 金额: $ 1.79万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591147/
• 关键词: Varicella-zoster virus; Cell tropism; Natural Killer

Cell tropism of varicella-zoster virus (VZV) Oka strain was investigated for the pathogenesis by the in vitro infection of peripheral blood mononuclear cells (PBMCs) obtained from healthy adults. After a short incubation of VZV and PBMCs,VZV DNA was quantified in sorted subsets of T cells of CD3,CD4 and CD45RO,B cells of CD19,CD20,CD21,CD22 and CD74, and NK cells of CD16,CD56 and CD57 using a real-time PCR assay. The copy numbers were relatively large in a part of NK and B cells. In the comparison between the positive and negative cells, NK cells of CD56 positive adsorbed VZV significantly more than did the negative cells (p=.008). This cell tropism may be one of mechanism of escaping from immunity to decrease the function in NK cells and may be associated with transient absence of NK cells in life threatening chickenpox which had been reported.

通过对健康成人外周血单核细胞的体外感染，研究了水痘带状疱疹病毒（VZV） Oka株的细胞趋向性发病机制。在VZV和PBMCs短暂孵育后，采用实时荧光定量检测VZV DNA在CD3、CD4和CD45RO的T细胞、CD19、CD20、CD21、CD22和CD74的B细胞以及CD16、CD56和CD57的NK细胞的亚群中。部分NK细胞和B细胞拷贝数较多。阳性和阴性细胞比较，CD56阳性NK细胞对VZV的吸附明显多于阴性细胞（p= 0.008）。这种细胞趋向性可能是NK细胞逃避免疫而降低功能的机制之一，并可能与已有报道的危及生命的水痘中NK细胞的短暂缺失有关。

项目成果

Characteristics of facial nerve plasy during childhood in Japan

日本儿童期面神经手术的特点

• 发表时间: 2006
• 期刊: Pediatr Internat 48
• 作者: Satoko Ogita;Kihei Terada;et.al
• 通讯作者: et.al

Characteristics of facial nerve plasy during childhood in Japan. -Varicella zoster virus association.

日本儿童时期面神经手术的特点。

• 发表时间: 2006
• 期刊: Pediatr Internat 48
• 作者: Ogita S;Terada K;et al.
• 通讯作者: et al.

Enhancement of immunity against VZV by giving live varicella vaccine to the elderly assessed by VZV skin test and IAHA, gpELISA antibody assay

• DOI: 10.1016/s0264-410x(03)00303-7
• 发表时间: 2003-09-08
• 期刊: VACCINE
• 影响因子: 5.5
• 作者: Takahashi, M;Okada, S;Yamanishi, K
• 通讯作者: Yamanishi, K

Elevated serum C-reactive protein. in mumps orchitis.

血清C反应蛋白升高。

• 发表时间: 2004
• 期刊: Pediatr Infect Dis J 23
• 作者: Niizuma T;Terada K;Kosaka Y;Daimon Y;Inoue M;Ogita S;Kataoka N;Tanaka K.
• 通讯作者: Tanaka K.

実践予防接種マニュアル

实用疫苗接种手册

• 发表时间: 2005
• 作者: Sakuraba;H. et al.;寺田喜平
• 通讯作者: 寺田喜平