Limbic Brain Hypometabolism in Patients Having Cancer : A PET Study

癌症患者边缘脑代谢减退：PET 研究

• 批准号: 10670819
• 负责人: ITOH Masatoshi
• 金额: $ 2.05万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670819/
• 关键词: Positron Emission Tomography; PET; Cerebral Metabolism; Cancer; Depression; Brain Function; 大脳辺縁系

Patients suffering from malignant disease are very prone to develop severe psychosomatic trauma due to the devastating nature of the ailment and aggressive treatment approach. Our study was aimed to document the psycho-psychiatric abnormalities developed in patients suffering from cancer using brain imaging technique. Brain images of cancer and benign patients were taken by positron emission tomography (PET) after infusion of [18F]-fluoro-deoxy-glucose as a tracer. The imaging results were compared between the cancer patients and the patients suffering a benign disease. The data were analyzed using statistical parametrical mapping technique (SPM96) developed by Friston et al (London, U.K.).Our results have well illustrated the following imaging findings in the brain substrates. (1) Cancer patients have shown regional metabolic abnormality in the limbic structures of the brain with a remarkable decrement and noticeable decline was observed also in the frontal cortex. (2) This metabolic decline has shown some noted correlation with the course of treatments. It was more widely and significantly distributed in patients studied at their initial admission to a hospital prior to application of any specific treatment. Subsequently, the regions were regressed markedly after the completion of the therapeutic regimen of chemotherapy and/or radiation therapy. However, similar extensive metabolic abnormalities were again noted in those patients in whom the cancer had recurred. (3) We have speculated that these abnormalities were strongly associated with psychological factors such as depressive and anxiety disorders which also was later confirmed by asking a standard psychological questionnaire.

恶性肿瘤患者由于疾病的破坏性和积极的治疗方法，很容易发展为严重的心身创伤。本研究旨在利用脑成像技术记录癌症患者的心理-精神异常。在输注[18F]-氟脱氧葡萄糖作为示踪剂后，通过正电子发射断层扫描（PET）拍摄癌症和良性患者的脑图像。比较了癌症患者和良性疾病患者的成像结果。使用Friston等人（英国伦敦）开发的统计参数映射技术（SPM 96）分析数据。我们的研究结果很好地说明了以下脑基底的成像结果。(1)癌症患者在大脑边缘结构中表现出局部代谢异常，在额叶皮层中也观察到显著的减少和明显的下降。(2)这种代谢下降显示出与治疗过程的一些显著相关性。在应用任何特定治疗之前首次入院时研究的患者中，其分布更广泛且更显著。随后，在完成化疗和/或放疗的治疗方案后，这些区域明显消退。然而，在那些癌症复发的患者中再次注意到类似的广泛代谢异常。(3)我们推测，这些异常与心理因素如抑郁和焦虑障碍密切相关，这也是后来通过询问标准心理问卷得到证实的。

项目成果

Tashiro M, Juengling FD, Reinhardt J, M, Itoh M et al.: "Reproducibility of PET Brain Mapping of Cancer Patients"Psycho-oncology. (in press). (2000)

Tashiro M、Juengling FD、Reinhardt J、M、Itoh M 等人：“癌症患者 PET 脑图谱的再现性”心理肿瘤学。

Tashiro M,Itoh M 他5名: "Observation of whole body metabolic change during running using PET to study neuromuscular interaction" J Intl Soc Life Info Sci. 16・3. 161-5 (1998)

Tashiro M、Itoh M 等 5 人：“使用 PET 观察跑步过程中的全身代谢变化以研究神经肌肉相互作用”J Intl Soc Life Info Sci 16・3（1998）。

Tashiro M,Juengling FD,Reinhardt J,M,Itoh M他8名: "Reproducibility of PET Brain Mapping of Cancer Patients"Psycho-oncology. (in press). (2000)

Tashiro M、Juengling FD、Reinhardt J、M、Itoh M 和其他 8 人：“癌症患者 PET 脑图的再现性”心理肿瘤学（2000 年出版）。

Tashiro M, Juengling F, Reinhardt M, et al.: "Psychological response and survival in breast cancer (correspondence)"The Lancet. 355. 405-406 (2000)

Tashiro M、Juengling F、Reinhardt M 等人：“乳腺癌的心理反应和生存（通讯）”《柳叶刀》。

伊藤正敏、山口慶一郎他 2名: "サイクロトロンとスーパーコンピューターを利用する三次元全身ポジトロン核医学画像法(PET)の概要"SENAC. 32・1. 27-31 (1999)

Masatoshi Ito、Keiichiro Yamaguchi 等 2 人：“使用回旋加速器和超级计算机的三维全身正电子核成像 (PET) 概述”SENAC 32・1 (1999)。